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dc.contributor.authorStalnaker, T.A.
dc.contributor.authorHoward, J.D.
dc.contributor.authorSchoenbaum, G.
dc.date.accessioned2019-11-20T15:51:41Z
dc.date.available2019-11-20T15:51:41Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85074675843&doi=10.7554%2feLife.49315&partnerID=40&md5=a3f7cab72b4447d33138df1e30ae0380
dc.identifier.urihttp://hdl.handle.net/10713/11418
dc.description.abstractDopamine neurons respond to errors in predicting value-neutral sensory information. These data, combined with causal evidence that dopamine transients support sensory-based associative learning, suggest that the dopamine system signals a multidimensional prediction error. Yet such complexity is not evident in the activity of individual neurons or population averages. How then do downstream areas know what to learn in response to these signals? One possibility is that information about content is contained in the pattern of firing across many dopamine neurons. Consistent with this, here we show that the pattern of firing across a small group of dopamine neurons recorded in rats signals the identity of a mis-predicted sensory event. Further, this same information is reflected in the BOLD response elicited by sensory prediction errors in human midbrain. These data provide evidence that ensembles of dopamine neurons provide highly specific teaching signals, opening new possibilities for how this system might contribute to learning.en_US
dc.description.urihttps://doi.org/10.7554/eLife.49315en_US
dc.language.isoen_USen_US
dc.publisherHoward Hughes Medical Instituteen_US
dc.relation.ispartofeLife
dc.subjectdopamineen_US
dc.subjecthumanen_US
dc.subjectlearningen_US
dc.subjectneuroscienceen_US
dc.subjectprediction erroren_US
dc.subjectraten_US
dc.titleDopamine neuron ensembles signal the content of sensory prediction errorsen_US
dc.typeArticleen_US
dc.identifier.doi10.7554/eLife.49315
dc.identifier.pmid31674910


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