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dc.contributor.authorChristenson, R.
dc.contributor.authorSeliger, S.
dc.contributor.authorCRIC Study Investigatorsen_US
dc.date.accessioned2019-11-20T15:51:40Z
dc.date.available2019-11-20T15:51:40Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85074741735&doi=10.1161%2fJAHA.119.012336&partnerID=40&md5=310ab918029b94ac3ca793f071362e7f
dc.identifier.urihttp://hdl.handle.net/10713/11412
dc.description.abstractBackground Cardiac biomarkers may signal mechanistic pathways involved in heart failure (HF), a leading complication in chronic kidney disease. We tested the associations of NT-proBNP (N-terminal pro-B-type natriuretic peptide), high-sensitivity troponin T (hsTnT), galectin-3, growth differentiation factor-15 (GDF-15), and soluble ST2 (sST2) with incident HF in chronic kidney disease. Methods and Results We examined adults with chronic kidney disease enrolled in a prospective, multicenter study. All biomarkers were measured at baseline. The primary outcome was incident HF. Secondary outcomes included HF with preserved ejection fraction (EF?50%) and reduced ejection fraction (EF<50%). Cox models were used to test the association of each cardiac biomarker with HF, adjusting for demographics, kidney function, cardiovascular risk factors, and medication use. Among 3314 participants, all biomarkers, with the exception of galectin-3, were significantly associated with increased risk of incident HF (hazard ratio per SD higher concentration of log-transformed biomarker): NT-proBNP (hazard ratio, 2.07; 95% CI, 1.79-2.39); hsTnT (hazard ratio, 1.38; 95% CI, 1.21-1.56); GDF-15 (hazard ratio, 1.44; 95% CI, 1.26-1.66) and sST2 (hazard ratio, 1.19; 95% CI, 1.05-1.35). Higher NT-proBNP, hsTnT, and GDF-15 were also associated with a greater risk of HF with reduced EF; while higher NT-proBNP GDF-15 and sST2 were associated with HF with preserved EF. Galectin-3 was not associated with either HF with reduced EF or HF with preserved EF. Conclusions In chronic kidney disease, elevations of NT-proBNP, hsTnT, GDF-15, sST2 were associated with incident HF. There was a borderline association of galectin-3 with incident HF. NT-proBNP and hsTnT were more strongly associated with HF with reduced EF, while the associations of the newer biomarkers GDF-15 and sST2 were stronger for HF with preserved EF.en_US
dc.description.sponsorshipThe study was supported by NIDDK R01 DK103612 (Bansal) and NIDDK R01DK104730 (Anderson). Roche Diagnostics provided partial funding for the NT-proBNP and hsTnT assays.en_US
dc.description.urihttps://doi.org/10.1161/JAHA.119.012336en_US
dc.language.isoen_USen_US
dc.publisherAmerican Heart Associationen_US
dc.relation.ispartofJournal of the American Heart Association
dc.subjectcardiac biomarkersen_US
dc.subjectchronic kidney diseaseen_US
dc.subjectheart failureen_US
dc.titleCardiac Biomarkers and Risk of Incident Heart Failure in Chronic Kidney Disease: The CRIC (Chronic Renal Insufficiency Cohort) Studyen_US
dc.typeArticleen_US
dc.identifier.doi10.1161/JAHA.119.012336
dc.identifier.pmid31645163


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