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dc.contributor.authorPaluskievicz, C.M.
dc.contributor.authorCao, X.
dc.contributor.authorZheng, P.
dc.contributor.authorLiu, Y.
dc.contributor.authorBromberg, J.S.
dc.date.accessioned2019-11-12T20:30:55Z
dc.date.available2019-11-12T20:30:55Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85074420815&doi=10.3389%2ffimmu.2019.02453&partnerID=40&md5=6e05bce56ddf9909235c11236e3d3ae2
dc.identifier.urihttp://hdl.handle.net/10713/11395
dc.description.abstractTreg play a central role in maintenance of self tolerance and homeostasis through suppression of self-reactive T cell populations. In addition to that role, Treg also survey cancers and suppress anti-tumor immune responses. Thus, understanding the unique attributes of Treg-tumor interactions may permit control of this pathologic suppression without interfering with homeostatic self-tolerance. This review will define the unique role of Treg in cancer growth, and the ways by which Treg inhibit a robust anti-tumor immune response. There will be specific focus placed on Treg homing to the tumor microenvironment (TME), TME formation of induced Treg (iTreg), mechanisms of suppression that underpin cancer immune escape, and trophic nonimmunologic effects of Treg on tumor cells. Copyright Copyright 2019 Paluskievicz, Cao, Abdi, Zheng, Liu and Bromberg.en_US
dc.description.urihttps://doi.org/10.3389/fimmu.2019.02453en_US
dc.language.isoen_USen_US
dc.publisherFrontiersen_US
dc.relation.ispartofFrontiers in immunology
dc.subjectanti-tumor immunityen_US
dc.subjectimmunosuppressionen_US
dc.subjectmetastasisen_US
dc.subjectTregen_US
dc.subjecttumor microenvironmenten_US
dc.titleT Regulatory Cells and Priming the Suppressive Tumor Microenvironmenten_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fimmu.2019.02453
dc.identifier.pmid31681327


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