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    T Regulatory Cells and Priming the Suppressive Tumor Microenvironment

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    Author
    Paluskievicz, C.M.
    Cao, X.
    Zheng, P.
    Liu, Y.
    Bromberg, J.S.
    Date
    2019
    Journal
    Frontiers in immunology
    Publisher
    Frontiers
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3389/fimmu.2019.02453
    Abstract
    Treg play a central role in maintenance of self tolerance and homeostasis through suppression of self-reactive T cell populations. In addition to that role, Treg also survey cancers and suppress anti-tumor immune responses. Thus, understanding the unique attributes of Treg-tumor interactions may permit control of this pathologic suppression without interfering with homeostatic self-tolerance. This review will define the unique role of Treg in cancer growth, and the ways by which Treg inhibit a robust anti-tumor immune response. There will be specific focus placed on Treg homing to the tumor microenvironment (TME), TME formation of induced Treg (iTreg), mechanisms of suppression that underpin cancer immune escape, and trophic nonimmunologic effects of Treg on tumor cells. Copyright Copyright 2019 Paluskievicz, Cao, Abdi, Zheng, Liu and Bromberg.
    Keyword
    anti-tumor immunity
    immunosuppression
    metastasis
    Treg
    tumor microenvironment
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074420815&doi=10.3389%2ffimmu.2019.02453&partnerID=40&md5=6e05bce56ddf9909235c11236e3d3ae2; http://hdl.handle.net/10713/11395
    ae974a485f413a2113503eed53cd6c53
    10.3389/fimmu.2019.02453
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    UMB Open Access Articles 2019

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