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dc.contributor.authorPalacios, A.M.
dc.contributor.authorHurley, K.M.
dc.contributor.authorBlack, M.M.
dc.date.accessioned2019-11-06T15:55:50Z
dc.date.available2019-11-06T15:55:50Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85074039415&doi=10.1111%2fmcn.12885&partnerID=40&md5=6beaa57cc1c97d6bd1ef4dbbe220dc73
dc.identifier.urihttp://hdl.handle.net/10713/11379
dc.description.abstractOne in four children younger than age five in Guatemala experiences anaemia (haemoglobin <11.0 g/dl). This study characterized the factors and micronutrient deficiencies associated with anaemia in a baseline cross-sectional sample of 182 Guatemalan infants/toddlers and 207 preschoolers, using generalized linear mixed models. Associations between anaemia and maternal, child and household variables, and biomarkers (soluble transferrin receptor, ferritin, zinc, folate, vitamin B12, C-reactive protein, and ?1-acid glycoprotein) were explored. Rates of anaemia were 56% among infants/toddlers and 12.1% among preschoolers. In children with anaemia, rates of iron deficiency (low ferritin based on inflammation status, and/or high soluble transferrin receptor, ?1.97 mg/L) and zinc deficiency (serum zinc <65 ?g/dl) were 81.1% and 53.7%, respectively. Folate deficiency (either plasma folate <3 ng/ml or erythrocyte folate <100 ng/ml) was 3.3%. Vitamin B12 deficiency (plasma vitamin B12 <148 pmol/L) was 7.5%. For infants and toddlers (<24 months), the odds ratio of anaemia was lower when higher number of adults lived in the household (OR = 0.69; 95% CI [0.53, 0.90]), and higher when children were zinc deficient (OR = 3.40; 95% CI [1.54, 7.47]). For preschoolers (36-60 months), the odds ratio of anaemia was lower for every additional month of age (OR = 0.90; 95% CI [0.81, 1.00]). Findings suggest that micronutrient deficiencies coexist in Guatemalan rural children, and zinc deficiency is associated with anaemia in children <24 months, highlighting the need of continued multidisciplinary interventions with multiple micronutrients. Further research examining how household composition, feeding practices, and accessibility to micronutrient supplements and to animal source foods is needed to incorporate strategies to improve the nutritional status of Guatemalan children. Copyright 2019 The Authors.en_US
dc.description.sponsorshipThis study was funded by The Mathile Institute for the Advancement of Human Nutrition and The Sackler Institute for Nutrition Sciences of the New York Academy of Sciences.en_US
dc.description.urihttps://doi.org/10.1111/mcn.12885en_US
dc.language.isoen_USen_US
dc.publisherBlackwell Publishing Ltden_US
dc.relation.ispartofMaternal and Child Nutrition
dc.subjectanaemiaen_US
dc.subjecthemoglobinen_US
dc.subjectinternational child health nutritionen_US
dc.subjectmicronutrient deficienciesen_US
dc.subjectundernutritionen_US
dc.subjectzincen_US
dc.titleZinc deficiency associated with anaemia among young children in rural Guatemalaen_US
dc.typeArticleen_US
dc.identifier.doi10.1111/mcn.12885
dc.identifier.pmid31595712


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