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dc.contributor.authorGrazioli, A.
dc.contributor.authorRabin, J.
dc.contributor.authorMadathil, R.J.
dc.contributor.authorKing, J.D.
dc.contributor.authorDiChiacchio, L.
dc.contributor.authorRector, R.P.
dc.contributor.authorDeatrick, K.B.
dc.contributor.authorWu, Z.J.
dc.contributor.authorHerr, D.L.
dc.date.accessioned2019-11-06T15:55:50Z
dc.date.available2019-11-06T15:55:50Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85073987324&doi=10.1177%2f0267659119871232&partnerID=40&md5=38caa5c51016b7db2f5e41504ae3a2ef
dc.identifier.urihttp://hdl.handle.net/10713/11377
dc.description.abstractThe ability of current renal replacement therapy modalities to achieve rapid solute removal is limited by membrane surface area and blood flow rate. Extracorporeal membrane oxygenation offers high blood flow and hemodynamic support that may be harnessed to overcome limitations in traditional renal replacement therapy. Using an extracorporeal membrane oxygenation circuit, we describe a high blood flow, high-efficiency hemofiltration technique using in-line hemofilters (hemoconcentrators) and standard replacement fluid to enhance solute clearance. Using this approach and a total of 5 L of replacement volume per treatment, creatinine (Cr) clearances of 8.3 L/hour and 11.2 L/hour using one and two hemoconcentrators, respectively, were achieved. With use of a high blood flow rate of up to 5 L/min, this hemofiltration technique can potentially offer clearance of 30 times that of continuous renal replacement therapy and of 6 times that of hemodialysis which may expand the ability to remove substances traditionally not considered removable via existing extracorporeal therapies. Copyright The Author(s) 2019.en_US
dc.description.urihttps://doi.org/10.1177/0267659119871232en_US
dc.language.isoen_USen_US
dc.publisherSAGE Publications Ltden_US
dc.relation.ispartofPerfusion (United Kingdom)
dc.subjectconvective clearanceen_US
dc.subjectextracorporeal therapyen_US
dc.subjecthemofiltrationen_US
dc.subjecthigh-flux dialysisen_US
dc.subjectrenal replacement therapyen_US
dc.titleHigh-efficiency, high-flux in-line hemofiltration using a high blood flow extracorporeal circuiten_US
dc.typeArticleen_US
dc.identifier.doi10.1177/0267659119871232
dc.identifier.pmid31526104


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