• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles 2019
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles 2019
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    High-efficiency, high-flux in-line hemofiltration using a high blood flow extracorporeal circuit

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Grazioli, A.
    Rabin, J.
    Madathil, R.J.
    King, J.D.
    DiChiacchio, L.
    Rector, R.P.
    Deatrick, K.B.
    Wu, Z.J.
    Herr, D.L.
    Date
    2019
    Journal
    Perfusion (United Kingdom)
    Publisher
    SAGE Publications Ltd
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1177/0267659119871232
    Abstract
    The ability of current renal replacement therapy modalities to achieve rapid solute removal is limited by membrane surface area and blood flow rate. Extracorporeal membrane oxygenation offers high blood flow and hemodynamic support that may be harnessed to overcome limitations in traditional renal replacement therapy. Using an extracorporeal membrane oxygenation circuit, we describe a high blood flow, high-efficiency hemofiltration technique using in-line hemofilters (hemoconcentrators) and standard replacement fluid to enhance solute clearance. Using this approach and a total of 5 L of replacement volume per treatment, creatinine (Cr) clearances of 8.3 L/hour and 11.2 L/hour using one and two hemoconcentrators, respectively, were achieved. With use of a high blood flow rate of up to 5 L/min, this hemofiltration technique can potentially offer clearance of 30 times that of continuous renal replacement therapy and of 6 times that of hemodialysis which may expand the ability to remove substances traditionally not considered removable via existing extracorporeal therapies. Copyright The Author(s) 2019.
    Keyword
    convective clearance
    extracorporeal therapy
    hemofiltration
    high-flux dialysis
    renal replacement therapy
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85073987324&doi=10.1177%2f0267659119871232&partnerID=40&md5=38caa5c51016b7db2f5e41504ae3a2ef; http://hdl.handle.net/10713/11377
    ae974a485f413a2113503eed53cd6c53
    10.1177/0267659119871232
    Scopus Count
    Collections
    UMB Open Access Articles 2019

    entitlement

    Related articles

    • Safety and Efficacy of Combined Extracorporeal CO2 Removal and Renal Replacement Therapy in Patients With Acute Respiratory Distress Syndrome and Acute Kidney Injury: The Pulmonary and Renal Support in Acute Respiratory Distress Syndrome Study.
    • Authors: Allardet-Servent J, Castanier M, Signouret T, Soundaravelou R, Lepidi A, Seghboyan JM
    • Issue date: 2015 Dec
    • Comparison of solute clearance in three modes of continuous renal replacement therapy.
    • Authors: Parakininkas D, Greenbaum LA
    • Issue date: 2004 May
    • Factors affecting urea clearance during continuous hemodiafiltration in the canine model.
    • Authors: Hiyama DT, Weiss RG, Ryckman FC
    • Issue date: 1989 Aug
    • Evaluation of Combined Extracorporeal Life Support and Continuous Renal Replacement Therapy on Hemodynamic Performance and Gaseous Microemboli Handling Ability in a Simulated Neonatal ECLS System.
    • Authors: Shank KR, Profeta E, Wang S, O'Connor C, Kunselman AR, Woitas K, Myers JL, Ündar A
    • Issue date: 2018 Apr
    • Solutes removal characteristics at various effluent rates during different continuous renal replacement therapy modalities.
    • Authors: Yu W, Zhuang F, Ma S, Zhu M, Ding F
    • Issue date: 2019 Jul
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.