High-efficiency, high-flux in-line hemofiltration using a high blood flow extracorporeal circuit
Author
Grazioli, A.Rabin, J.
Madathil, R.J.
King, J.D.
DiChiacchio, L.
Rector, R.P.
Deatrick, K.B.
Wu, Z.J.
Herr, D.L.
Date
2019Journal
Perfusion (United Kingdom)Publisher
SAGE Publications LtdType
Article
Metadata
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The ability of current renal replacement therapy modalities to achieve rapid solute removal is limited by membrane surface area and blood flow rate. Extracorporeal membrane oxygenation offers high blood flow and hemodynamic support that may be harnessed to overcome limitations in traditional renal replacement therapy. Using an extracorporeal membrane oxygenation circuit, we describe a high blood flow, high-efficiency hemofiltration technique using in-line hemofilters (hemoconcentrators) and standard replacement fluid to enhance solute clearance. Using this approach and a total of 5 L of replacement volume per treatment, creatinine (Cr) clearances of 8.3 L/hour and 11.2 L/hour using one and two hemoconcentrators, respectively, were achieved. With use of a high blood flow rate of up to 5 L/min, this hemofiltration technique can potentially offer clearance of 30 times that of continuous renal replacement therapy and of 6 times that of hemodialysis which may expand the ability to remove substances traditionally not considered removable via existing extracorporeal therapies. Copyright The Author(s) 2019.Keyword
convective clearanceextracorporeal therapy
hemofiltration
high-flux dialysis
renal replacement therapy
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85073987324&doi=10.1177%2f0267659119871232&partnerID=40&md5=38caa5c51016b7db2f5e41504ae3a2ef; http://hdl.handle.net/10713/11377ae974a485f413a2113503eed53cd6c53
10.1177/0267659119871232
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