Quantitative immunomorphological analysis of heat shock proteins in thyroid follicular adenoma and carcinoma tissues reveals their potential for differential diagnosis and points to a role in carcinogenesis
Date
2019Journal
Applied Sciences (Switzerland)Publisher
MDPI AGType
Article
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Hsp27, Hsp60, Hsp70, and Hsp90 are chaperones that play a crucial role in cellular homeostasis and differentiation, but they may be implicated in carcinogenesis. Follicular neoplasms of the thyroid include follicular adenoma and follicular carcinoma. The former is a very frequent benign encapsulated nodule, whereas the other is a nodule that infiltrates the capsule, blood vessels and the adjacent parenchyma, with a tendency to metastasize. The main objective was to assess the potential of the Hsps in differential diagnosis and carcinogenesis. We quantified by immunohistochemistry Hsp27, Hsp60, Hsp70, and Hsp90 on thin sections of human thyroid tissue with follicular adenoma or follicular carcinoma, comparing the tumor with the adjacent peritumoral tissue. Hsp60, Hsp70, and Hsp90 were increased in follicular carcinoma compared to follicular adenoma, while Hsp27 showed no difference. Histochemical quantification of Hsp60, Hsp70, and Hsp90 allows diagnostic distinction between follicular adenoma and carcinoma, and between tumor and adjacent non-tumoral tissue. The quantitative variations of these chaperones in follicular carcinoma suggest their involvement in tumorigenesis, for instance in processes such as invasion of thyroid parenchyma and metastasization. Copyright 2019 by the authors.Sponsors
This work was done under the agreement between IEMEST (Italy) and IMET (USA) (this is IMET contribution number IMET 19-016).Keyword
CarcinogenesisChaperonopathies
Differential diagnosis
Follicular adenoma
Follicular carcinoma
Hsp27
Hsp60
Hsp70
Hsp90
Molecular chaperone
Thyroid
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074193930&doi=10.3390%2fapp9204324&partnerID=40&md5=4757b5aff298a760f538b66f8f37316d; http://hdl.handle.net/10713/11375ae974a485f413a2113503eed53cd6c53
10.3390/app9204324