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    Quantitative immunomorphological analysis of heat shock proteins in thyroid follicular adenoma and carcinoma tissues reveals their potential for differential diagnosis and points to a role in carcinogenesis

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    Author
    Pitruzzella, A.
    Paladino, L.
    de Macario, E.C.
    Date
    2019
    Journal
    Applied Sciences (Switzerland)
    Publisher
    MDPI AG
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3390/app9204324
    Abstract
    Hsp27, Hsp60, Hsp70, and Hsp90 are chaperones that play a crucial role in cellular homeostasis and differentiation, but they may be implicated in carcinogenesis. Follicular neoplasms of the thyroid include follicular adenoma and follicular carcinoma. The former is a very frequent benign encapsulated nodule, whereas the other is a nodule that infiltrates the capsule, blood vessels and the adjacent parenchyma, with a tendency to metastasize. The main objective was to assess the potential of the Hsps in differential diagnosis and carcinogenesis. We quantified by immunohistochemistry Hsp27, Hsp60, Hsp70, and Hsp90 on thin sections of human thyroid tissue with follicular adenoma or follicular carcinoma, comparing the tumor with the adjacent peritumoral tissue. Hsp60, Hsp70, and Hsp90 were increased in follicular carcinoma compared to follicular adenoma, while Hsp27 showed no difference. Histochemical quantification of Hsp60, Hsp70, and Hsp90 allows diagnostic distinction between follicular adenoma and carcinoma, and between tumor and adjacent non-tumoral tissue. The quantitative variations of these chaperones in follicular carcinoma suggest their involvement in tumorigenesis, for instance in processes such as invasion of thyroid parenchyma and metastasization. Copyright 2019 by the authors.
    Sponsors
    This work was done under the agreement between IEMEST (Italy) and IMET (USA) (this is IMET contribution number IMET 19-016).
    Keyword
    Carcinogenesis
    Chaperonopathies
    Differential diagnosis
    Follicular adenoma
    Follicular carcinoma
    Hsp27
    Hsp60
    Hsp70
    Hsp90
    Molecular chaperone
    Thyroid
    Show allShow less
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074193930&doi=10.3390%2fapp9204324&partnerID=40&md5=4757b5aff298a760f538b66f8f37316d; http://hdl.handle.net/10713/11375
    ae974a485f413a2113503eed53cd6c53
    10.3390/app9204324
    Scopus Count
    Collections
    UMB Open Access Articles 2019

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