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    Left ventricular hypertrophy in a contemporary cohort of autosomal dominant polycystic kidney disease patients

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    Author
    Chen, H.
    Watnick, T.
    Hong, S.N.
    Daly, B.
    Li, Y.
    Seliger, S.L.
    Date
    2019
    Journal
    BMC nephrology
    Publisher
    BMC
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1186/s12882-019-1555-z
    Abstract
    Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) often develop hypertension in childhood or early adulthood. Although this could result in left ventricular hypertrophy (LVH), a major risk factor for cardiovascular morbidity and mortality, prior studies of LVH in ADPKD have yielded conflicting results. We estimated the prevalence of LVH using consensus echocardiography criteria and examined the independent association of ADPKD severity with LV mass in a contemporary cohort of ADPKD patients. Methods Adults with ADPKD and eGFR> 15 ml/min/1.73m2 were enrolled in a single-center study. Left Ventricular Mass (LVM) was quantified using 2D echocardiography, and LVH was defined using gender-specific cut-points of LVM and LVM indexed to body surface area (LVMI) from consensus guidelines. Total Kidney Volume (TKV) was quantified using Magnetic Resonance Imaging, and GFR was estimated from serum creatinine using the CKD-Epi equation. Multiple linear regression was used to estimate the association of TKV and eGFR with LVM and LVMI, adjusting for potential confounders. Results Among 126 participants (78% with hypertension), median age was 46 years, median eGFR 63 ml/min/1.73 m2, and median [IQR] systolic blood pressure was 125 [116–133] mmHg. Prevalence of LVH was 21.4% as defined by LVMI and was not significantly different (p = 0.8) between those with and without HTN, and was similar (21.4%) after excluding those (N = 21) with known cardiac disease. Greater TKV and lower eGFR were directly correlated with greater LVMI (p = .016 and p < .001, respectively). In multiple linear regression models accounting for potential confounders including blood pressure, greater TKV was positively associated with LVM (β^ =0.19, p = 0.04). Conclusions In a contemporary cohort of ADPKD patients with well-controlled blood pressure, the prevalence of LVH is high, and ADPKD severity as reflected by TKV is independently associated with greater LV mass. These results may suggest a relationship between ADPKD pathophysiology and increased LV mass.
    Keyword
    Polycystic Kidney, Autosomal Dominant
    Hypertrophy, Left Ventricular
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074135851&doi=10.1186%2fs12882-019-1555-z&partnerID=40&md5=56fd136bf60c087bf29dbc1e7072a33d; http://hdl.handle.net/10713/11368
    ae974a485f413a2113503eed53cd6c53
    10.1186/s12882-019-1555-z
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    UMB Open Access Articles 2019

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