Placental but Not Peripheral Plasmodium falciparum Infection During Pregnancy Is Associated With Increased Risk of Malaria in Infancy
JournalJournal of Infectious Diseases
PublisherOxford University Press
MetadataShow full item record
AbstractPregnancy-associated Plasmodium falciparum infection impacts the health of mothers and newborns, but little is known about the effects of these infections on infant susceptibility to malaria. We followed 473 mother-infant pairs during pregnancy and through 2 years of age. We observed that children born to mothers with placental malaria, but not those born to mothers with peripheral infection without evidence of placental sequestration, had increased risk of malaria during the first year of life compared with children born to mothers with no malaria during pregnancy. Malaria infections with placental sequestration have long-lasting impact on infant susceptibility to malaria infection. Copyright 2017 The Author.
SponsorsThis work was supported by the US National Institutes of Health (grant numbers U01AI087624 and K24AI114996 to M. K. L. and T32GM092237, T32AI007540, and F30AI114195 to S. B.); the American Society of Tropical Medicine and Hygiene (Benjamin H. Kean Travel Fellowship to S. B.); the Infectious Diseases Society of America Medical Scholars Program (to S. B.); and the University of Maryland Global Health Interprofessional Council (to S. B.).
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85030610856&doi=10.1093%2finfdis%2fjix372&partnerID=40&md5=cf2aacea302981955755a19a0f284e76; http://hdl.handle.net/10713/11361