Show simple item record

dc.contributor.authorValencia, A.P.
dc.contributor.authorIyer, S.R.
dc.contributor.authorSpangenburg, E.E.
dc.date.accessioned2019-11-01T12:49:39Z
dc.date.available2019-11-01T12:49:39Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85033599422&doi=10.1186%2fs12891-017-1789-5&partnerID=40&md5=0db895cd8400398489240f1b20282b06
dc.identifier.urihttp://hdl.handle.net/10713/11341
dc.description.abstractBackground: Rotator cuff (RTC) tears are a common clinical problem resulting in adverse changes to the muscle, but there is limited information comparing histopathology to contractile function. This study assessed supraspinatus force and susceptibility to injury in the rat model of RTC tear, and compared these functional changes to histopathology of the muscle. Methods: Unilateral RTC tears were induced in male rats via tenotomy of the supraspinatus and infraspinatus. Maximal tetanic force and susceptibility to injury of the supraspinatus muscle were measured in vivo at day 2 and day 15 after tenotomy. Supraspinatus muscles were weighed and harvested for histologic analysis of the neuromuscular junction (NMJ), intramuscular lipid, and collagen. Results: Tenotomy resulted in eventual atrophy and weakness. Despite no loss in muscle mass at day 2 there was a 30% reduction in contractile force, and a decrease in NMJ continuity and size. Reduced force persisted at day 15, a time point when muscle atrophy was evident but NMJ morphology was restored. At day 15, torn muscles had decreased collagen-packing density and were also more susceptible to contraction-induced injury. Conclusion: Muscle size and histopathology are not direct indicators of overall RTC contractile health. Changes in NMJ morphology and collagen organization were associated with changes in contractile function and thus may play a role in response to injury. Although our findings are limited to the acute phase after a RTC tear, the most salient finding is that RTC tenotomy results in increased susceptibility to injury of the supraspinatus. Copyright 2017 The Author(s).en_US
dc.description.urihttps://doi.org/10.1186/s12891-017-1789-5en_US
dc.language.isoen_USen_US
dc.publisherBioMed Central Ltd.en_US
dc.relation.ispartofBMC Musculoskeletal Disorders
dc.subjectCollagen organizationen_US
dc.subjectContractilityen_US
dc.subjectEccentric injuryen_US
dc.subjectMuscle forceen_US
dc.subjectNeuromuscular junctionen_US
dc.subjectRaten_US
dc.titleImpaired contractile function of the supraspinatus in the acute period following a rotator cuff tearen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/s12891-017-1789-5
dc.identifier.pmid29121906


This item appears in the following Collection(s)

Show simple item record