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    Impaired contractile function of the supraspinatus in the acute period following a rotator cuff tear

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    Author
    Valencia, A.P.
    Iyer, S.R.
    Spangenburg, E.E.
    Date
    2017
    Journal
    BMC Musculoskeletal Disorders
    Publisher
    BioMed Central Ltd.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1186/s12891-017-1789-5
    Abstract
    Background: Rotator cuff (RTC) tears are a common clinical problem resulting in adverse changes to the muscle, but there is limited information comparing histopathology to contractile function. This study assessed supraspinatus force and susceptibility to injury in the rat model of RTC tear, and compared these functional changes to histopathology of the muscle. Methods: Unilateral RTC tears were induced in male rats via tenotomy of the supraspinatus and infraspinatus. Maximal tetanic force and susceptibility to injury of the supraspinatus muscle were measured in vivo at day 2 and day 15 after tenotomy. Supraspinatus muscles were weighed and harvested for histologic analysis of the neuromuscular junction (NMJ), intramuscular lipid, and collagen. Results: Tenotomy resulted in eventual atrophy and weakness. Despite no loss in muscle mass at day 2 there was a 30% reduction in contractile force, and a decrease in NMJ continuity and size. Reduced force persisted at day 15, a time point when muscle atrophy was evident but NMJ morphology was restored. At day 15, torn muscles had decreased collagen-packing density and were also more susceptible to contraction-induced injury. Conclusion: Muscle size and histopathology are not direct indicators of overall RTC contractile health. Changes in NMJ morphology and collagen organization were associated with changes in contractile function and thus may play a role in response to injury. Although our findings are limited to the acute phase after a RTC tear, the most salient finding is that RTC tenotomy results in increased susceptibility to injury of the supraspinatus. Copyright 2017 The Author(s).
    Keyword
    Collagen organization
    Contractility
    Eccentric injury
    Muscle force
    Neuromuscular junction
    Rat
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85033599422&doi=10.1186%2fs12891-017-1789-5&partnerID=40&md5=0db895cd8400398489240f1b20282b06; http://hdl.handle.net/10713/11341
    ae974a485f413a2113503eed53cd6c53
    10.1186/s12891-017-1789-5
    Scopus Count
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    UMB Open Access Articles 2017

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