Risk for cognitive impairment across 22 measures of cognitive ability in early-stage chronic kidney disease
JournalNephrology Dialysis Transplantation
PublisherOxford University Press
MetadataShow full item record
AbstractBackground: Chronic kidney disease (CKD) is a significant risk factor for cognitive impairment. Previous studies have examined differences in cognitive impairment between persons with and without CKD using multiple cognitive outcomes, but few have done this for an extensive battery of cognitive tests. We relate early-stage CKD to two indices of impairment for 22 measures of cognitive ability. Methods: The study was community-based and cross-sectional with 898 individuals free from dementia and end-stage renal disease. Estimated glomerular filtration rate (eGFR) was calculated using the chronic kidney disease epidemiology collaboration equation and classified as <60 or ≥60 mL/min/1.73 m2, based on consensus definitions of Stage 3 or greater CKD. The eGFR classifications were related to modest [≥1 standard deviation (SD) below the mean] and severe (≥1.5 SD below the mean) impairment on each measure using logistic regression analyses adjusting for potential risk factors. Results: A total of 146 individuals (16.3%) had eGFR <60 mL/min/1.73 m2 (mean 51.6 ± 10.1 mL/min/1.73 m2). These participants had significantly greater risk for modestly impaired abilities in the scanning and tracking and visual-spatial organization/memory (VSOM) domains after accounting for comorbidity-related risk factors [odds ratios (ORs) between 1.68 and 2.16], as well as greater risk for severely impaired functioning in the language domain (OR = 2.65). Conclusions: Participants with eGFR <60 mL/min/1.73 m2 were at higher risk for cognitive impairment than those with eGFR ≥60 mL/min/1.73 m2 on the majority of cognitive abilities, specifically those within the VSOM, Language, and scanning and tracking domains. Targeted screening for cognitive deficits in kidney disease patients early in their disease course may be warranted. Copyright The Author 2017.
SponsorsThis study was supported by grants R01HL67358 and R01HL081290 from the National Heart, Lung and Blood Institute, National Institutes of Health (USA) and research grant R01AG03055 from the National Institute on Aging, National Institutes of Health (USA) to the University of Maine
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85015979707&doi=10.1093%2fndt%2fgfw005&partnerID=40&md5=9de18469673f3dd729bf0001a5440d1c; http://hdl.handle.net/10713/11338
- Chronic kidney disease, creatinine and cognitive functioning.
- Authors: Elias MF, Elias PK, Seliger SL, Narsipur SS, Dore GA, Robbins MA
- Issue date: 2009 Aug
- Cognitive Impairment and Progression of CKD.
- Authors: Kurella Tamura M, Yaffe K, Hsu CY, Yang J, Sozio S, Fischer M, Chen J, Ojo A, DeLuca J, Xie D, Vittinghoff E, Go AS, Chronic Renal Insufficiency Cohort (CRIC) Study Investigators.
- Issue date: 2016 Jul
- Decline in renal functioning is associated with longitudinal decline in global cognitive functioning, abstract reasoning and verbal memory.
- Authors: Davey A, Elias MF, Robbins MA, Seliger SL, Dore GA
- Issue date: 2013 Jul
- The Brain in Kidney Disease (BRINK) Cohort Study: Design and Baseline Cognitive Function.
- Authors: Murray AM, Bell EJ, Tupper DE, Davey CS, Pederson SL, Amiot EM, Miley KM, McPherson L, Heubner BM, Gilbertson DT, Foley RN, Drawz PE, Slinin Y, Rossom RC, Lakshminarayan K, Vemuri P, Jack CR, Knopman DS
- Issue date: 2016 Apr
- Kidney function and cognitive impairment among older hospitalized patients: a comparison of four glomerular filtration rate equations.
- Authors: Pierpaoli E, Fabi K, Lenci FF, Ricci M, Di Rosa M, Onder G, Volpato S, Ruggiero C, Cherubini A, Corsonello A, Lattanzio F
- Issue date: 2020 May