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    Perioperative management of rare coagulation factor deficiency states in cardiac surgery

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    Author
    Strauss, E.R.
    Mazzeffi, M.A.
    Williams, B.
    Date
    2017
    Journal
    British Journal of Anaesthesia
    Publisher
    Oxford University Press
    Type
    Conference/Congress
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1093/bja/aex198
    Abstract
    Rare bleeding disorders (RBDs) include the hereditary deficiency of fibrinogen, factor (F)II, FV, FV + FVIII, FVII, FX, FXI or FXIII. RBDs do not confer a protective effect against atheromatous plaque formation, and thus the need for cardiovascular (CV) surgery in RBD patients is expected to increase with improved healthcare access (diagnosis and management) and longevity of the population. Clinical data regarding the management of RBDs in this setting are sparse, but the perioperative care team is obliged to gain a better understanding on available biological and pharmacological hemostatic agents. Perioperative management of RBDs in CV surgery is further complicated by heparin anticoagulation, haemodilution, and consumption of procoagulant and anticoagulant proteins associated with cardiopulmonary bypass (CPB). The aims of this review are to summarize pathophysiology of RBDs and laboratory monitoring pertinent to CV surgery, available factor replacement agents, and to provide the framework for perioperative coagulation management of RBD patients. Copyright 2017 The Author.
    Keyword
    blood coagulation factors
    blood transfusion
    coagulants
    thoracic surgery
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85029808843&doi=10.1093%2fbja%2faex198&partnerID=40&md5=65261ceb175cd1eefcdb6c012ac438a7; http://hdl.handle.net/10713/11331
    ae974a485f413a2113503eed53cd6c53
    10.1093/bja/aex198
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    UMB Open Access Articles 2017

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