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dc.contributor.authorRamaswamy, B.
dc.contributor.authorRoy, S.
dc.contributor.authorApolo, A.B.
dc.date.accessioned2019-11-01T12:49:38Z
dc.date.available2019-11-01T12:49:38Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85032013045&doi=10.3389%2ffncel.2017.00268&partnerID=40&md5=de88c488b10ff1d4666d18ace8a74acb
dc.identifier.urihttp://hdl.handle.net/10713/11322
dc.description.abstractCisplatin (cis-diamminedichloroplatinum) is widely used as a chemotherapeutic drug for genitourinary, breast, lung and head and neck cancers. Though effective in inducing apoptosis in cancer cells, cisplatin treatment causes severe hearing loss among patients. Steroids have been shown to mitigate cisplatin-induced hearing loss. However, steroids may interfere with the anti-cancer properties of cisplatin if administered systemically, or are rapidly cleared from the middle and inner ear and hence lack effectiveness when administered intra-tympanically. In this work, we deliver prednisolone-loaded nanoparticles magnetically to the cochlea of cisplatin-treated mice. This magnetic delivery method substantially reduced hearing loss in treated animals at high frequency compared to control animals or animals that received intra-tympanicmethylprednisolone. The method also protected the outer hair cells from cisplatin-mediated ototoxicity. Copyright 2017 Ramaswamy, Roy, Apolo, Shapiro and Depireux.en_US
dc.description.urihttps://doi.org/10.3389/fncel.2017.00268en_US
dc.language.isoen_USen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Cellular Neuroscience
dc.subjectCisplatinen_US
dc.subjectDrug deliveryen_US
dc.subjectHair cellsen_US
dc.subjectMagnetic nanoparticlesen_US
dc.subjectOtotoxicityen_US
dc.titleMagnetic nanoparticle mediated steroid delivery mitigates cisplatin induced hearing lossen_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fncel.2017.00268


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