Magnetic nanoparticle mediated steroid delivery mitigates cisplatin induced hearing loss
Date
2017Journal
Frontiers in Cellular NeurosciencePublisher
Frontiers Media S.A.Type
Article
Metadata
Show full item recordAbstract
Cisplatin (cis-diamminedichloroplatinum) is widely used as a chemotherapeutic drug for genitourinary, breast, lung and head and neck cancers. Though effective in inducing apoptosis in cancer cells, cisplatin treatment causes severe hearing loss among patients. Steroids have been shown to mitigate cisplatin-induced hearing loss. However, steroids may interfere with the anti-cancer properties of cisplatin if administered systemically, or are rapidly cleared from the middle and inner ear and hence lack effectiveness when administered intra-tympanically. In this work, we deliver prednisolone-loaded nanoparticles magnetically to the cochlea of cisplatin-treated mice. This magnetic delivery method substantially reduced hearing loss in treated animals at high frequency compared to control animals or animals that received intra-tympanicmethylprednisolone. The method also protected the outer hair cells from cisplatin-mediated ototoxicity. Copyright 2017 Ramaswamy, Roy, Apolo, Shapiro and Depireux.Identifier to cite or link to this item
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032013045&doi=10.3389%2ffncel.2017.00268&partnerID=40&md5=de88c488b10ff1d4666d18ace8a74acb; http://hdl.handle.net/10713/11322ae974a485f413a2113503eed53cd6c53
10.3389/fncel.2017.00268