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    Magnetic nanoparticle mediated steroid delivery mitigates cisplatin induced hearing loss

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    Author
    Ramaswamy, B.
    Roy, S.
    Apolo, A.B.
    Date
    2017
    Journal
    Frontiers in Cellular Neuroscience
    Publisher
    Frontiers Media S.A.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3389/fncel.2017.00268
    Abstract
    Cisplatin (cis-diamminedichloroplatinum) is widely used as a chemotherapeutic drug for genitourinary, breast, lung and head and neck cancers. Though effective in inducing apoptosis in cancer cells, cisplatin treatment causes severe hearing loss among patients. Steroids have been shown to mitigate cisplatin-induced hearing loss. However, steroids may interfere with the anti-cancer properties of cisplatin if administered systemically, or are rapidly cleared from the middle and inner ear and hence lack effectiveness when administered intra-tympanically. In this work, we deliver prednisolone-loaded nanoparticles magnetically to the cochlea of cisplatin-treated mice. This magnetic delivery method substantially reduced hearing loss in treated animals at high frequency compared to control animals or animals that received intra-tympanicmethylprednisolone. The method also protected the outer hair cells from cisplatin-mediated ototoxicity. Copyright 2017 Ramaswamy, Roy, Apolo, Shapiro and Depireux.
    Keyword
    Cisplatin
    Drug delivery
    Hair cells
    Magnetic nanoparticles
    Ototoxicity
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032013045&doi=10.3389%2ffncel.2017.00268&partnerID=40&md5=de88c488b10ff1d4666d18ace8a74acb; http://hdl.handle.net/10713/11322
    ae974a485f413a2113503eed53cd6c53
    10.3389/fncel.2017.00268
    Scopus Count
    Collections
    UMB Open Access Articles 2017

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