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    In vivo verification of particle therapy: How Compton camera configurations affect 3D image quality

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    Author
    Mackin, D.
    Draeger, E.
    Peterson, S.
    Date
    2017
    Journal
    Journal of Physics: Conference Series
    Publisher
    Institute of Physics Publishing
    Type
    Conference/Congress
    
    Metadata
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    See at
    https://doi.org/10.1088/1742-6596/847/1/012045
    Abstract
    The steep dose gradients enabled by the Bragg peaks of particle therapy beams are a double edged sword. They enable highly conformal dose distributions, but even small deviations from the planned beam range can cause overdosing of healthy tissue or under-dosing of the tumour. To reduce this risk, particle therapy treatment plans include margins large enough to account for all the sources of range uncertainty, which include patient setup errors, patient anatomy changes, and CT number to stopping power ratios. Any system that could verify the beam range in vivo, would allow reduced margins and more conformal dose distributions. Toward our goal developing such a system based on Compton camera (CC) imaging, we studied how three configurations (single camera, parallel opposed, and orthogonal) affect the quality of the 3D images. We found that single CC and parallel opposed configurations produced superior images in 2D. The increase in parallax produced by an orthogonal CC configuration was shown to be beneficial in producing artefact free 3D images.
    Keyword
    particle therapy beams
    Tumors
    Imaging, Three-Dimensional
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021951919&doi=10.1088%2f1742-6596%2f847%2f1%2f012045&partnerID=40&md5=61bc168fa15a13f35740edb8c66bc862; http://hdl.handle.net/10713/11307
    ae974a485f413a2113503eed53cd6c53
    10.1088/1742-6596/847/1/012045
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    UMB Open Access Articles 2017

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