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    Role of glycemic control on hospital-related outcomes in patients with diabetes mellitus undergoing renal transplantation

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    Author
    Lamos, E.M.
    Wijesinha, M.A.
    Ramhmdani, S.
    Date
    2017
    Journal
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
    Publisher
    Dove Medical Press Ltd.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.2147/DMSO.S118437
    Abstract
    Objective: To compare length of stay (LOS) and incidence of hypoglycemic events and infections in hospitalized patients with diabetes mellitus (DM) undergoing renal transplantation, among groups of patients defined by admission glucose and mean inpatient daily glucose. Methods: A retrospective analysis of 190 charts of patients with DM who underwent renal transplantation over a 2-year period was conducted. Patients were grouped according to admission glucose and mean inpatient daily glucose (≤140 mg/dL, 141–180 mg/dL, and >180 mg/dL). Results: Admission glucose was not associated with LOS. A mean inpatient daily glucose of ≤140 mg/dL was associated with a longer LOS compared to a mean inpatient daily glucose of >180 mg/dL (p=0.03). Patients with an admission glucose of ≤140 mg/dL had approximately half the rate of hypoglycemic events compared to those with admission glucose of 141−180 mg/dL (odds ratio [OR]=2.1; p=0.02) or >180 mg/dL (OR=1.9; p=0.04). However, patients whose mean daily glucose was ≤140 mg/dL had approximately twice the rate of hypoglycemic events than those whose mean daily glucose was 141−180 mg/dL (OR=0.4; p=0.01) or >180 mg/dL (OR=0.4; p=0.004). The incidence of infections was low and was not associated with admission or mean daily glucose levels. Conclusion: Lower mean daily inpatient glucose levels (≤140 mg/dL) are associated with longer LOS and greater incidence of hypoglycemic episodes in diabetes patients undergoing renal transplantation. Our findings suggest that target blood glucose levels of 140−180 mg/dL may be appropriate in this specific population. Additional prospective research is needed to confirm these findings. Copyright 2017 Lamos et al.
    Sponsors
    This work was supported by American Diabetes Association grant #1-08-CR-60 (KS).
    Keyword
    Diabetes mellitus
    Hypoglycemia
    Infection
    Length of stay
    Renal transplantation
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009865567&doi=10.2147%2fDMSO.S118437&partnerID=40&md5=7d5945b1ee1dc4a454eeea7e5a5053c1; http://hdl.handle.net/10713/11301
    ae974a485f413a2113503eed53cd6c53
    10.2147/DMSO.S118437
    Scopus Count
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    UMB Open Access Articles 2017

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