• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles 2017
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles 2017
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Intracranial applications of mr imaging-guided focused ultrasound

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Khanna, N.
    Gandhi, D.
    Steven, A.
    Date
    2017
    Journal
    American Journal of Neuroradiology
    Publisher
    American Society of Neuroradiology
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3174/ajnr.A4902
    Abstract
    Initially used in the treatment of prostate cancer and uterine fibroids, the role of focused ultrasound has expanded as transcranial acoustic wave distortion and other limitations have been overcome. Its utility relies on focal energy deposition via acoustic wave propagation. The duty cycle and intensity of focused ultrasound influence the rate of energy deposition and result in unique physiologic and biomechanical effects. Thermal ablation via high-intensity continuous exposure generates coagulative necrosis of tissues. High-intensity, pulsed application reduces temporally averaged energy deposition, resulting in mechanical effects, including reversible, localized BBB disruption, which enhances neurotherapeutic agent delivery. While the precise mechanisms remain unclear, low-intensity, pulsed exposures can influence neuronal activity with preservation of cytoarchitecture. Its noninvasive nature, high-resolution, radiationfree features allow focused ultrasound to compare favorably with other modalities. We discuss the physical characteristics of focused ultrasound devices, the biophysical mechanisms at the tissue level, and current and emerging applications.
    Keyword
    focused ultrasound
    Brain
    Ultrasonic Therapy--methods
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015765696&doi=10.3174%2fajnr.A4902&partnerID=40&md5=39ca02d55425e95536f794f89b910fc8; http://hdl.handle.net/10713/11292
    ae974a485f413a2113503eed53cd6c53
    10.3174/ajnr.A4902
    Scopus Count
    Collections
    UMB Open Access Articles 2017

    entitlement

    Related articles

    • MR-guided focused ultrasound: a potentially disruptive technology.
    • Authors: Bradley WG Jr
    • Issue date: 2009 Jul
    • Ultrasound focusing using magnetic resonance acoustic radiation force imaging: application to ultrasound transcranial therapy.
    • Authors: Hertzberg Y, Volovick A, Zur Y, Medan Y, Vitek S, Navon G
    • Issue date: 2010 Jun
    • MR imaging-controlled focused ultrasound ablation: a noninvasive image-guided surgery.
    • Authors: Jolesz FA, Hynynen K, McDannold N, Tempany C
    • Issue date: 2005 Aug
    • High-intensity focused ultrasound surgery of the brain: part 1--A historical perspective with modern applications.
    • Authors: Jagannathan J, Sanghvi NT, Crum LA, Yen CP, Medel R, Dumont AS, Sheehan JP, Steiner L, Jolesz F, Kassell NF
    • Issue date: 2009 Feb
    • Clinical applications for magnetic resonance guided high intensity focused ultrasound (MRgHIFU): present and future.
    • Authors: Ellis S, Rieke V, Kohi M, Westphalen AC
    • Issue date: 2013 Aug
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.