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dc.contributor.authorHajjar, A.M.
dc.contributor.authorErnst, R.K.
dc.contributor.authorYi, J.
dc.date.accessioned2019-11-01T12:49:34Z
dc.date.available2019-11-01T12:49:34Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85031013831&doi=10.1371%2fjournal.pone.0186308&partnerID=40&md5=5eb3b09ccc380c534b8060eab772fd46
dc.identifier.urihttp://hdl.handle.net/10713/11281
dc.description.abstractTo address the role of Toll-like receptor 4 (TLR4) single nucleotide polymorphisms (SNP) in lipopolysaccharide (LPS) recognition, we generated mice that differed only in the sequence of TLR4. We used a bacterial artificial chromosome (BAC) transgenic approach and TLR4/ MD-2 knockout mice to specifically examine the role of human TLR4 variants in recognition of LPS. Using in vitro and in vivo assays we found that the expression level rather than the sequence of TLR4 played a larger role in recognition of LPS, especially hypoacylated LPS. Copyright 2017 Hajjar et al.en_US
dc.description.urihttps://doi.org/10.1371/journal.pone.0186308en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofPLoS ONE
dc.subject.meshLipopolysaccharides--pharmacologyen_US
dc.subject.meshToll-Like Receptor 4--geneticsen_US
dc.subject.meshToll-Like Receptor 4--metabolismen_US
dc.titleExpression level of human TLR4 rather than sequence is the key determinant of LPS responsivenessen_US
dc.typeArticleen_US
dc.identifier.doi10.1371/journal.pone.0186308
dc.identifier.pmid29020088


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