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dc.contributor.authorGardner, M.P.H.
dc.contributor.authorConroy, J.S.
dc.contributor.authorShaham, M.H.
dc.date.accessioned2019-11-01T12:49:34Z
dc.date.available2019-11-01T12:49:34Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85034226770&doi=10.1016%2fj.neuron.2017.10.026&partnerID=40&md5=b14f4a086698ea16981caa27ca6972e6
dc.identifier.urihttp://hdl.handle.net/10713/11277
dc.description.abstractHow do we choose between goods that have different subjective values, like apples and oranges? Neuroeconomics proposes that this is done by reducing complex goods to a single unitary value to allow comparison. This value is computed "on the fly" from the underlying model of the goods space, allowing decisions to meet current needs. This is termed "model-based" behavior to distinguish it from pre-determined, habitual, or "model-free" behavior. The lateral orbitofrontal cortex (OFC) supports model-based behavior in rats and primates, but whether the OFC is necessary for economic choice is less clear. Here we tested this question by optogenetically inactivating the lateral OFC in rats in a classic model-based task and during economic choice. Contrary to predictions, inactivation disrupted model-based behavior without affecting economic choice. In the current study, Gardner et al. show that optogenetic inactivation of orbitofrontal cortex has no effect on an economic choice behavior modeled after primate studies. Using the same cohort of rats, they find that inactivation of the OFC does disrupt devaluation-sensitive behavior.en_US
dc.description.sponsorshipThis work was supported by the Intramural Research Program at the National Institute on Drug Abuse (G.S.). The authors thank Dr. Karl Deisseroth and the Gene Therapy Center at the University of North Carolina at Chapel Hill for providing viral reagents. The opinions expressed in this article are the authors' own and do not reflect the views of the NIH or the North Carolina Department of Health and Human Services.en_US
dc.description.urihttps://doi.org/10.1016/j.neuron.2017.10.026en_US
dc.language.isoen_USen_US
dc.publisherCell Pressen_US
dc.relation.ispartofNeuron
dc.subject.meshBehavior, Animalen_US
dc.subject.meshChoice Behavior--physiologyen_US
dc.subject.meshFrontal Lobe--physiologyen_US
dc.titleLateral Orbitofrontal Inactivation Dissociates Devaluation-Sensitive Behavior and Economic Choiceen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.neuron.2017.10.026
dc.identifier.pmid29154127


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