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dc.contributor.authorFeng, D.
dc.contributor.authorLi, Q.
dc.contributor.authorYu, H.
dc.date.accessioned2019-11-01T12:49:34Z
dc.date.available2019-11-01T12:49:34Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85017012729&doi=10.1038%2fsrep45754&partnerID=40&md5=cba1ef655e54b5268ee586fc1d574ebe
dc.identifier.urihttp://hdl.handle.net/10713/11273
dc.description.abstractThe calcifying shell is an excellent model for studying biomineralization and evolution. However, the molecular mechanisms of shell formation are only beginning to be elucidated in Mollusca. It is known that shell matrix proteins (SMPs) play important roles in shell formation. With increasing data of shell matrix proteomes from various species, we carried out a BLASTp bioinformatics analysis using the shell matrix proteome from Crassostrea gigas against 443 SMPs from nine other species. The highly conserved tyrosinase and chitin related proteins were identified in bivalve. In addition, the relatively conserved proteins containing domains of carbonic anhydrase, Sushi, Von Willebrand factor type A, and chitin binding, were identified from all the ten species. Moreover, 25 genes encoding SMPs were annotated and characterized that are involved in CaCO 3 crystallization and represent chitin related or ECM related proteins. Together, data from these analyses provide new knowledge underlying the molecular mechanism of shell formation in C.gigas, supporting a refined shell formation model including chitin and ECM-related proteins. Copyright 2017 The Author(s).en_US
dc.description.sponsorshipNational Natural Science Foundation of China (31372524)en_US
dc.description.urihttps://doi.org/10.1038/srep45754en_US
dc.language.isoen_USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofScientific Reports
dc.subject.meshAnimal Shells--metabolismen_US
dc.subject.meshCrassostrea--geneticsen_US
dc.subject.meshCrassostrea--metabolismen_US
dc.subject.meshProteome--geneticsen_US
dc.titleIdentification of conserved proteins from diverse shell matrix proteome in Crassostrea gigas: Characterization of genetic bases regulating shell formationen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/srep45754
dc.identifier.pmid28374770


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