Show simple item record

dc.contributor.authorFan, F.
dc.contributor.authorZou, Y.
dc.contributor.authorTan, Y.
dc.date.accessioned2019-11-01T12:49:34Z
dc.date.available2019-11-01T12:49:34Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85022054494&doi=10.1038%2fs41598-017-04829-9&partnerID=40&md5=6c2387460522138453f5ef7a95e230b6
dc.identifier.urihttp://hdl.handle.net/10713/11272
dc.description.abstractThis study aimed to test how an 8-week training using computerized cognitive remediation therapy (CCRT) would modify resting brain functional activity and improve cognitive function in patients with schizophrenia. Twenty-seven patients with schizophrenia were recruited and randomized into two groups: CCRT or treatment-as-usual (TAU). The CCRT group received 40 sessions of computerized cognitive training over an eight-week period. There was a significant treatment group × time interaction on the processing speed (trail making test: F = 8.14, P = 0.01) and a trend in problem solving (mazes test: P = 0.06). Post-hoc tests showed that CCRT but not TAU significantly improved scores from baseline to end-of-treatment on these two cognitive assessments. For the resting brain functional activity, significant group × time interaction effect was found in the medial prefrontal cortex (mPFC)/anterior cingulate cortex (ACC) and brainstem pons region. Post-hoc tests showed that there was significant increased activity in the mPFC/ACC in CCRT but not TAU group. In this small sample study, computerized cognitive remediation therapy is shown to enhance mPFC/ACC activity even at resting state and improve cognitive function in patients with schizophrenia. If replicated, this community and clinic accessible therapy may assist cognitive remediation effort for people with schizophrenia. Copyright 2017 The Author(s).en_US
dc.description.urihttps://doi.org/10.1038/s41598-017-04829-9en_US
dc.language.isoen_USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofScientific Reports
dc.subjectcomputerized cognitive remediation therapyen_US
dc.subject.meshNeuroimagingen_US
dc.subject.meshOutcome Assessment (Health Care)en_US
dc.subject.meshSchizophreniaen_US
dc.titleComputerized cognitive remediation therapy effects on resting state brain activity and cognition in schizophreniaen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41598-017-04829-9
dc.identifier.pmid28684776


This item appears in the following Collection(s)

Show simple item record