• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles 2017
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles 2017
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Computerized cognitive remediation therapy effects on resting state brain activity and cognition in schizophrenia

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Fan, F.
    Zou, Y.
    Tan, Y.
    Date
    2017
    Journal
    Scientific Reports
    Publisher
    Nature Publishing Group
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1038/s41598-017-04829-9
    Abstract
    This study aimed to test how an 8-week training using computerized cognitive remediation therapy (CCRT) would modify resting brain functional activity and improve cognitive function in patients with schizophrenia. Twenty-seven patients with schizophrenia were recruited and randomized into two groups: CCRT or treatment-as-usual (TAU). The CCRT group received 40 sessions of computerized cognitive training over an eight-week period. There was a significant treatment group × time interaction on the processing speed (trail making test: F = 8.14, P = 0.01) and a trend in problem solving (mazes test: P = 0.06). Post-hoc tests showed that CCRT but not TAU significantly improved scores from baseline to end-of-treatment on these two cognitive assessments. For the resting brain functional activity, significant group × time interaction effect was found in the medial prefrontal cortex (mPFC)/anterior cingulate cortex (ACC) and brainstem pons region. Post-hoc tests showed that there was significant increased activity in the mPFC/ACC in CCRT but not TAU group. In this small sample study, computerized cognitive remediation therapy is shown to enhance mPFC/ACC activity even at resting state and improve cognitive function in patients with schizophrenia. If replicated, this community and clinic accessible therapy may assist cognitive remediation effort for people with schizophrenia. Copyright 2017 The Author(s).
    Keyword
    computerized cognitive remediation therapy
    Neuroimaging
    Outcome Assessment (Health Care)
    Schizophrenia
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85022054494&doi=10.1038%2fs41598-017-04829-9&partnerID=40&md5=6c2387460522138453f5ef7a95e230b6; http://hdl.handle.net/10713/11272
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41598-017-04829-9
    Scopus Count
    Collections
    UMB Open Access Articles 2017

    entitlement

    Related articles

    • Improving social functioning in community-dwelling patients with schizophrenia: a randomized controlled computer cognitive remediation therapy trial with six months follow-up.
    • Authors: Zhu X, Fan H, Fan F, Zhao Y, Tan Y, Yang F, Wang Z, Xue F, Xiao C, Li W, Li Z, Ma L, Zou Y, Tan S
    • Issue date: 2020 May
    • Prefrontal brain network connectivity indicates degree of both schizophrenia risk and cognitive dysfunction.
    • Authors: Unschuld PG, Buchholz AS, Varvaris M, van Zijl PC, Ross CA, Pekar JJ, Hock C, Sweeney JA, Tamminga CA, Keshavan MS, Pearlson GD, Thaker GK, Schretlen DJ
    • Issue date: 2014 May
    • Learning potential on the WCST in schizophrenia is related to the neuronal integrity of the anterior cingulate cortex as measured by proton magnetic resonance spectroscopy.
    • Authors: Ohrmann P, Kugel H, Bauer J, Siegmund A, Kölkebeck K, Suslow T, Wiedl KH, Rothermundt M, Arolt V, Pedersen A
    • Issue date: 2008 Dec
    • Nicotine effects on cognitive remediation training outcome in people with schizophrenia: A pilot study.
    • Authors: Hahn B, Shrieves ME, Yuille MB, Buchanan RW, Wells AK
    • Issue date: 2019 Oct
    • Lateral and medial hypofrontality in first-episode schizophrenia: functional activity in a medication-naive state and effects of short-term atypical antipsychotic treatment.
    • Authors: Snitz BE, MacDonald A 3rd, Cohen JD, Cho RY, Becker T, Carter CS
    • Issue date: 2005 Dec
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.