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    Vaginal Candida spp. genomes from women with vulvovaginal candidiasis

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    Author
    Bradford, L.L.
    Chibucos, M.C.
    Ma, B.
    Date
    2017
    Journal
    Pathogens and Disease
    Publisher
    Oxford University Press
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1093/femspd/ftx061
    Abstract
    Candida albicans is the predominant cause of vulvovaginal candidiasis (VVC). Little is known regarding the genetic diversity of Candida spp. in the vagina or the microvariations in strains over time that may contribute to the development of VVC. This study reports the draft genome sequences of four C. albicans and one C. glabrata strains isolated from women with VVC. An SNP-based whole-genome phylogeny indicates that these isolates are closely related; however, phylogenetic distances between them suggest that there may be genetic adaptations driven by unique host environments. These sequences will facilitate further comparative analyses and ultimately improve our understanding of genetic variation in isolates of Candida spp. that are associated with VVC.
    Sponsors
    Research reported in this publication was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under Award Number F31AI116023 and UH2AI083264.
    Keyword
    Candida albicans
    Candida glabrata
    Clinical isolates
    Single nucleotide polymorphisms (SNP)
    Yeast infection
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028626279&doi=10.1093%2ffemspd%2fftx061&partnerID=40&md5=15e661cc960b2b826773391c93c22254; http://hdl.handle.net/10713/11266
    ae974a485f413a2113503eed53cd6c53
    10.1093/femspd/ftx061
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