Developing and evaluating a flexible wireless microcoil array based integrated interface for epidural cortical stimulation
JournalInternational Journal of Molecular Sciences
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AbstractStroke leads to serious long-term disability. Electrical epidural cortical stimulation has made significant improvements in stroke rehabilitation therapy. We developed a preliminary wireless implantable passive interface, which consists of a stimulating surface electrode, receiving coil, and single flexible passive demodulated circuit printed by flexible printed circuit (FPC) technique and output pulse voltage stimulus by inductively coupling an external circuit. The wireless implantable board was implanted in cats' unilateral epidural space for electrical stimulation of the primary visual cortex (V1) while the evoked responses were recorded on the contralateral V1 using a needle electrode. The wireless implantable board output stable monophasic voltage stimuli. The amplitude of the monophasic voltage output could be adjusted by controlling the voltage of the transmitter circuit within a range of 5-20 V. In acute experiment, cortico-cortical evoked potential (CCEP) response was recorded on the contralateral V1. The amplitude of N2 in CCEP was modulated by adjusting the stimulation intensity of the wireless interface. These results demonstrated that a wireless interface based on a microcoil array can offer a valuable tool for researchers to explore electrical stimulation in research and the dura mater-electrode interface can effectively transmit electrical stimulation. Copyright 2017 by the authors.
SponsorsThe work was supported by Natural Science Foundation of Chongqing in China (CSTC2013JCYJA0763) and by R01HL118084 from NIH (to Xiaofeng Jia), and Maryland Stem Cell Research Fund (2013-MSCRFE-146-00) (to Xiaofeng Jia).
KeywordEpidural cortical stimulation
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85012008461&doi=10.3390%2fijms18020335&partnerID=40&md5=4c6ef5ca09153117353c876f5910cac5; http://hdl.handle.net/10713/11259