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    Lenalidomide-induced eosinophilic pneumonia

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    Author
    Toma, A.
    Rapoport, A.P.
    Burke, A.
    Date
    2017
    Journal
    Respirology Case Reports
    Publisher
    Wiley-Blackwell Publishing Ltd
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1002/rcr2.233
    Abstract
    Multiple myeloma is a plasma cell dyscrasia accounting for 10% of haematologic malignancies. Lenalidomide is an immunomodulatory drug analogous to thalidomide that is approved for use in patients with myelodysplastic syndrome, and in combination with dexamethasone for refractory or relapsed multiple myeloma. Lenalidomide is preferred to thalidomide because of reduced toxicity, and pulmonary side effects are considered rare. We present, to our knowledge, an unusual and first reported case of a patient with relapsed multiple myeloma who received lenalidomide after autologous stem cell transplant, then developed eosinophilic pneumonia presenting as dyspnoea, peripheral eosinophilia, and bilateral pulmonary opacities. Bronchoscopy with bronchoalveolar lavage was negative for infection, and transbronchial lung biopsies showed eosinophilic pneumonia. After discontinuation of lenalidomide and initiation of prednisone therapy, his dyspnoea improved and eosinophilia resolved; however, symptoms recurred when the drug was restarted at a lower dose, confirming its causative role. In the absence of infection, clinicians should always bear in mind drug toxicity in the differential diagnosis of patients receiving lenalidomide and related agents. Copyright 2017 The Authors.
    Keyword
    Eosinophilia
    Lenalidomide
    Lung injury
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020181173&doi=10.1002%2frcr2.233&partnerID=40&md5=1c4d8ddefcf93311845d9a83c9ecdc73; http://hdl.handle.net/10713/11256
    ae974a485f413a2113503eed53cd6c53
    10.1002/rcr2.233
    Scopus Count
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    UMB Open Access Articles 2017

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