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dc.contributor.authorEkoru, K.
dc.contributor.authorDoumatey, A.
dc.contributor.authorBentley, A.R.
dc.contributor.authorChen, G.
dc.contributor.authorZhou, J.
dc.contributor.authorShriner, D.
dc.contributor.authorFasanmade, O.
dc.contributor.authorOkafor, G.
dc.contributor.authorEghan, B., Jr.
dc.contributor.authorAgyenim-Boateng, K.
dc.contributor.authorAdeleye, J.
dc.contributor.authorBalogun, W.
dc.contributor.authorAmoah, A.
dc.contributor.authorAcheampong, J.
dc.contributor.authorJohnson, T.
dc.contributor.authorOli, J.
dc.contributor.authorAdebamowo, C.
dc.contributor.authorCollins, F.
dc.contributor.authorDunston, G.
dc.contributor.authorAdeyemo, A.
dc.contributor.authorRotimi, C.
dc.date.accessioned2019-10-31T12:24:22Z
dc.date.available2019-10-31T12:24:22Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85073715194&doi=10.1016%2fj.eclinm.2019.09.001&partnerID=40&md5=b7a542037badf191a03b4106094b54d2
dc.identifier.urihttp://hdl.handle.net/10713/11242
dc.description.abstractBackground: Context-specific evidence of the spectrum of type 2 diabetes (T2D) burden is essential for setting priorities and designing interventions to reduce associated morbidity and mortality. However, there are currently limited data on the burden of T2D complications and comorbidity in sub-Saharan Africa (SSA). Methods: T2D complications and comorbidities were assessed in 2,784 participants with diabetes enrolled from tertiary health centres and contextualised in 3,209 individuals without diabetes in Nigeria, Ghana and Kenya. T2D complications and comorbidities evaluated included cardiometabolic, ocular, neurological and renal characteristics. Findings: The most common complications/comorbidities among the T2D participants were hypertension (71%; 95% CI 69–73), hyperlipidaemia (34%; 95% CI 32–36), and obesity (27%; 95% CI 25–29). Additionally, the prevalence of cataracts was 32% (95% CI 30–35), diabetic retinopathy 15% (95% CI 13–17), impaired renal function 13% (95% CI 12–15), and erectile dysfunction (in men) 35% (95% CI 32–38). T2D population-attributable fraction for these comorbidities ranged between 6 and 64%. Interpretation: The burden of diabetes complications and comorbidity is substantial in SSA highlighting the urgent need for innovative public health strategies that prioritise promotion of healthy lifestyles for prevention and early detection of T2D. Also needed are strategies to strengthen health care system capacities to provide treatment and care for diabetes complications.en_US
dc.description.sponsorshipThe study was supported in part by the Intramural Research Program of the National Institutes of Health (NIH) in the Center for Research on Genomics and Global Health (CRGGH). The CRGGH is supported by the National Human Genome Research Institute (NHGRI), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the Office of the Director at the NIH ( 1ZIAHG200362 ). Support for participant recruitment and initial genetic studies of the AADM study was provided by NIH grant No. 3T37TW00041-03S2 from the Office of Research on Minority Health.en_US
dc.description.urihttps://doi.org/10.1016/j.eclinm.2019.09.001en_US
dc.language.isoen_USen_US
dc.relation.ispartofEClinicalMedicine
dc.subjectCo-morbidityen_US
dc.subjectComplicationsen_US
dc.subjectEpidemiologyen_US
dc.subjectSub-Sahara Africaen_US
dc.subjectType 2 Diabetesen_US
dc.titleType 2 diabetes complications and comorbidity in Sub-Saharan Africansen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.eclinm.2019.09.001
dc.identifier.pmidLancet Publishing Group


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