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dc.contributor.authorKalaria, S.N.
dc.contributor.authorKelly, D.L.
dc.date.accessioned2019-10-22T14:48:38Z
dc.date.available2019-10-22T14:48:38Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85073369615&doi=10.2147%2fNDT.S216803&partnerID=40&md5=c67a9cbde95591c4d9036655febcfbaa
dc.identifier.urihttp://hdl.handle.net/10713/11195
dc.description.abstractAlthough clozapine has demonstrated superior efficacy in patients with schizophrenia and other serious mental health illness, drug utilization rates are significantly low due to safety concerns and administration challenges. Previous research indicates that current barriers to clozapine use include lack of confidence and knowledge by prescriber, therapeutic monitoring requirements, lack of support and infrastructure to for adequate monitoring and patient adherence, and inadequate understanding of clozapine’s benefit-risk profile by policy makers and payers. One potential solution to optimizing clozapine therapy and improving clinical outcomes is the use of point-of-care testing (POCT) devices. Although the drug development process for currently used therapeutics is widely acknowledged, little is known regarding the development of POCT devices by the clinical community. The aim of this review is to provide a summary of the regulatory approval process and current availability of POCT devices for monitoring clozapine therapeutics. The potential role of POCT devices in clinical trials to inform personalized dosing strategies and improve patient outcomes will also be discussed.en_US
dc.description.urihttps://doi.org/10.2147/NDT.S216803en_US
dc.language.isoen_USen_US
dc.publisherDove Medical Press Ltd.en_US
dc.relation.ispartofNeuropsychiatric Disease and Treatment
dc.subjectpatient outcomesen_US
dc.subjectpoint-of-care testing devicesen_US
dc.subjectregulatoryen_US
dc.subject.meshClozapineen_US
dc.subject.meshDrug Monitoringen_US
dc.subject.meshSchizophreniaen_US
dc.titleDevelopment of point-of-care testing devices to improve clozapine prescribing habits and patient outcomesen_US
dc.typeArticleen_US
dc.identifier.doi10.2147/NDT.S216803


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