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    Development of point-of-care testing devices to improve clozapine prescribing habits and patient outcomes

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    Author
    Kalaria, S.N.
    Kelly, D.L.
    Date
    2019
    Journal
    Neuropsychiatric Disease and Treatment
    Publisher
    Dove Medical Press Ltd.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.2147/NDT.S216803
    Abstract
    Although clozapine has demonstrated superior efficacy in patients with schizophrenia and other serious mental health illness, drug utilization rates are significantly low due to safety concerns and administration challenges. Previous research indicates that current barriers to clozapine use include lack of confidence and knowledge by prescriber, therapeutic monitoring requirements, lack of support and infrastructure to for adequate monitoring and patient adherence, and inadequate understanding of clozapine’s benefit-risk profile by policy makers and payers. One potential solution to optimizing clozapine therapy and improving clinical outcomes is the use of point-of-care testing (POCT) devices. Although the drug development process for currently used therapeutics is widely acknowledged, little is known regarding the development of POCT devices by the clinical community. The aim of this review is to provide a summary of the regulatory approval process and current availability of POCT devices for monitoring clozapine therapeutics. The potential role of POCT devices in clinical trials to inform personalized dosing strategies and improve patient outcomes will also be discussed.
    Keyword
    patient outcomes
    point-of-care testing devices
    regulatory
    Clozapine
    Drug Monitoring
    Schizophrenia
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85073369615&doi=10.2147%2fNDT.S216803&partnerID=40&md5=c67a9cbde95591c4d9036655febcfbaa; http://hdl.handle.net/10713/11195
    ae974a485f413a2113503eed53cd6c53
    10.2147/NDT.S216803
    Scopus Count
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    UMB Open Access Articles 2019

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