• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles 2019
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles 2019
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    A novel role for the actin-binding protein drebrin in regulating opiate addiction

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Martin, J.A.
    Chandra, R.
    Dietz, K.C.
    Lobo, M.K.
    Date
    2019
    Journal
    Nature Communications
    Publisher
    Nature Publishing Group
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1038/s41467-019-12122-8
    Abstract
    Persistent transcriptional and morphological events in the nucleus accumbens (NAc) and other brain reward regions contribute to the long-lasting behavioral adaptations that characterize drug addiction. Opiate exposure reduces the density of dendritic spines on medium spiny neurons of the NAc; however, the underlying transcriptional and cellular events mediating this remain unknown. We show that heroin self-administration negatively regulates the actin-binding protein drebrin in the NAc. Using virus-mediated gene transfer, we show that drebrin overexpression in the NAc is sufficient to decrease drug seeking and increase dendritic spine density, whereas drebrin knockdown potentiates these effects. We demonstrate that drebrin is transcriptionally repressed by the histone modifier HDAC2, which is relieved by pharmacological inhibition of histone deacetylases. Importantly, we demonstrate that heroin-induced adaptations occur only in the D1+ subset of medium spiny neurons. These findings establish an essential role for drebrin, and upstream transcriptional regulator HDAC2, in opiate-induced plasticity in the NAc. Copyright 2019, The Author(s).
    Sponsors
    This work was supported by the National Institutes of Health (no. NIDA R01DA037257, NIDA R01DA037257-S1, NIDA R21DA044486, NIDA R01DA046818, NIDA R01DA038613, NIDA R01DA037618, NINDS F99NS108543, and NIGMS R25GM09545902).
    Keyword
    drebrin
    nucleus acumbens
    Heroin
    Microfilament Proteins--physiology
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072150420&doi=10.1038%2fs41467-019-12122-8&partnerID=40&md5=52f93cf30ce635865e5c75e6c6caf989; http://hdl.handle.net/10713/11169
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41467-019-12122-8
    Scopus Count
    Collections
    UMB Open Access Articles 2019

    entitlement

    Related articles

    • Interactions between drebrin and Ras regulate dendritic spine plasticity.
    • Authors: Biou V, Brinkhaus H, Malenka RC, Matus A
    • Issue date: 2008 Jun
    • The role of drebrin in dendritic spines.
    • Authors: Koganezawa N, Hanamura K, Sekino Y, Shirao T
    • Issue date: 2017 Oct
    • Drebrin-dependent actin clustering in dendritic filopodia governs synaptic targeting of postsynaptic density-95 and dendritic spine morphogenesis.
    • Authors: Takahashi H, Sekino Y, Tanaka S, Mizui T, Kishi S, Shirao T
    • Issue date: 2003 Jul 23
    • Role of Drebrin in Synaptic Plasticity.
    • Authors: Sekino Y, Koganezawa N, Mizui T, Shirao T
    • Issue date: 2017
    • Histone deacetylase mediates the decrease in drebrin cluster density induced by amyloid beta oligomers.
    • Authors: Ishizuka Y, Shimizu H, Takagi E, Kato M, Yamagata H, Mikuni M, Shirao T
    • Issue date: 2014 Oct
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.