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dc.contributor.authorAyaz, R.
dc.contributor.authorAyas, S.
dc.contributor.authorAşoglu, M.R.en_US
dc.date.accessioned2019-10-15T19:01:32Z
dc.date.available2019-10-15T19:01:32Z
dc.date.issued2018
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85072814688&doi=10.4274%2fTJOD.99835&partnerID=40&md5=8e9f9a9ba3a87b9494de8efec8287688
dc.identifier.urihttp://hdl.handle.net/10713/11168
dc.description.abstractObjective: To compare the successes of clomiphene citrate (CC) alone, pure human urinary follicle-stimulating hormone (uFSH) alone, and both combined sequentially in patients with unexplained subfertility couples undergoing intrauterine insemination (IUI). Materials and Methods: Patients aged 18-38 years who had a normal uterine cavity, at least one normal fallopian tube, and regular menses and were unable to conceive despite unprotected intercourse for at least 12 months were randomized to receive CC alone, uFSH alone, or sequential CC and uFSH before a single IUI. The primary outcomes were clinical pregnancy and live birth rates. The study was approved by the ethics committee of our institution. Results: A total of 135 patients were randomized, and 121 of these were able to complete the study. Of these, 30% (n=36) had CC alone, 34% (n=41) had uFSH alone, and 36% (n=44) had sequential CC and uFSH. The three groups did not significantly differ in terms of age, duration of infertility, hormone levels, and semen parameters. For CC alone, uFSH alone, and sequential CC plus uFSH groups, pregnancy rates were 8.3%, 17.1%, and 18.2%, respectively (p>0.05), and live birth rates were 8.3%, 12.1%, and 13.6%, respectively (p>0.05). Conclusion: In women with unexplained infertility, use of uFSH seemed to increase the success rate compared with CC alone. The sequential regime can significantly reduce the treatment cost if gonadotropin/IUI cycles are planned.en_US
dc.description.urihttps://doi.org/10.4274/TJOD.99835en_US
dc.language.isoen_USen_US
dc.publisherTurkish Society of Obstetrics and Gynecologyen_US
dc.relation.ispartofTurk Jinekoloji ve Obstetrik Dernegi Dergisi
dc.subjectClomiphene citrateen_US
dc.subjectIntrauterine inseminatonen_US
dc.subjectUnexplained subfertilityen_US
dc.subjectUrinary follicle-stimulating hormoneen_US
dc.titleUse of clomiphene citrate alone, urinary follicle-stimulating hormone alone, or both combined sequentially in patients with unexplained subfertility undergoing intrauterine insemination: A randomized trialen_US
dc.typeArticleen_US
dc.identifier.doi10.4274/TJOD.99835


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