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    Toward a better understanding of neuronal migration deficits in autism spectrum disorders

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    Author
    Pan, Y.-H.
    Wu, N.
    Yuan, X.-B.
    Date
    2019
    Journal
    Frontiers in Cell and Developmental Biology
    Publisher
    Frontiers Media S.A.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3389/fcell.2019.00205
    Abstract
    Newborn neurons in developing brains actively migrate from germinal zones to designated regions before being wired into functional circuits. The motility and trajectory of migrating neurons are regulated by both extracellular factors and intracellular signaling cascades. Defects in the molecular machinery of neuronal migration lead to mis-localization of affected neurons and are considered as an important etiology of multiple developmental disorders including epilepsy, dyslexia, schizophrenia (SCZ), and autism spectrum disorders (ASD). However, the mechanisms that link neuronal migration deficits to the development of these diseases remain elusive. This review focuses on neuronal migration deficits in ASD. From a translational perspective, we discuss (1) whether neuronal migration deficits are general neuropathological characteristics of ASD; (2) how the phenotypic heterogeneity of neuronal migration disorders is generated; (3) how neuronal migration deficits lead to functional defects of brain circuits; and (4) how therapeutic intervention of neuronal migration deficits can be a potential treatment for ASD. Copyright 2019 Pan, Wu and Yuan.
    Sponsors
    This work was supported by grants from the National Natural Science Foundation of China (31771116 and 31871501), Simons Foundation (296143), and East China Normal University (11300-120215-10452).
    Keyword
    Autism-spectrum disorders
    Brain structural abnormalities
    E/I balance
    Mechanism-based therapy
    Neuronal migration
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072921591&doi=10.3389%2ffcell.2019.00205&partnerID=40&md5=5af7cb33dc40e858aee7c4a6c4ac8fd0; http://hdl.handle.net/10713/11167
    ae974a485f413a2113503eed53cd6c53
    10.3389/fcell.2019.00205
    Scopus Count
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