Dramatic Response of Leptomeningeal Carcinomatosis to Nivolumab in PD-L1 Highly Expressive Non-small Cell Lung Cancer: A Case Report
Date
2019Journal
Frontiers in OncologyPublisher
Frontiers Media S.A.Type
Article
Metadata
Show full item recordAbstract
In a patient who had been diagnosed of located squamous cell lung carcinoma, pneumonectomy, and adjuvant chemotherapy were performed. Brain recurrence and subsequent lung metastatic disease were uncontrolled by neurosurgery, holocranial radiotherapy, and first-line chemotherapy. In August 2015, appearance of leptomeningeal carcinomatosis triggered severe clinical deterioration and threatened the patient's life. Anti-PD1 immune checkpoint inhibitor Nivolumab was initiated in an attempt to stop tumor growth, achieving a spectacular brain and pulmonary complete response and clinical improvement, without serious adverse effects. High expression PD-L1 level (100%) was found in the pathological tissue sample. Nivolumab was maintained for more than 2 years and stopped in December 2017 after 28 months of treatment, with no disease evidence. More than 3 years after its onset, the patient maintains an outstanding PS with complete tumor response and no evidence of disease in last surveillance CT scan and brain MRI. © Copyright 2019 Arias Ron, Labandeira, Areses Manrique, Sampedro Domarco, Abdulkader, García-Mata, Rolfo, González-Rivas and Fírvida.Sponsors
The authors would like to thank all members of the study team, the patient and their family. Funding. The study was supported by Fundación Biomédica Galicia Sur.Identifier to cite or link to this item
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072949818&doi=10.3389%2ffonc.2019.00819&partnerID=40&md5=e2575b9ebad8bb9799bbee0786d0a53f; http://hdl.handle.net/10713/11165ae974a485f413a2113503eed53cd6c53
10.3389/fonc.2019.00819