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dc.contributor.authorSengupta, P.P.
dc.contributor.authorKramer, C.M.
dc.contributor.authorNarula, J.
dc.date.accessioned2019-10-08T19:43:55Z
dc.date.available2019-10-08T19:43:55Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85028988393&doi=10.1016%2fj.jcmg.2017.07.001&partnerID=40&md5=fd655bed935a12484492726a7487d4d6
dc.identifier.urihttp://hdl.handle.net/10713/11152
dc.description.abstractThe need for noninvasive assessment of cardiac volumes and ejection fraction (EF) ushered in the use of cardiac imaging techniques in heart failure (HF) trials that investigated the roles of pharmacological and device-based therapies. However, in contrast to HF with reduced EF (HFrEF), modern HF pharmacotherapy has not improved outcomes in HF with preserved EF (HFpEF), largely attributed to patient heterogeneity and incomplete understanding of pathophysiological insights underlying the clinical presentations of HFpEF. Modern cardiac imaging methods offer insights into many sets of changes in cardiac tissue structure and function that can precisely link cause with cardiac remodeling at organ and tissue levels to clinical presentations in HF. This has inspired investigators to seek a more comprehensive understanding of HF presentations using imaging techniques. This article summarizes the available evidence regarding the role of cardiac imaging in HF. Furthermore, we discuss the value of cardiac imaging techniques in identifying HF patient subtypes who share similar causes and mechanistic pathways that can be targeted using specific HF therapies.en_US
dc.description.urihttps://doi.org/10.1016/j.jcmg.2017.07.001en_US
dc.language.isoen_USen_US
dc.publisherElsevier Inc.en_US
dc.relation.ispartofJACC: Cardiovascular Imaging
dc.subjectcardiac imagingen_US
dc.subjectclinical trialsen_US
dc.subjectHFen_US
dc.subjectleft ventricular remodelingen_US
dc.titleThe Potential of Clinical Phenotyping of Heart Failure With Imaging Biomarkers for Guiding Therapies: A Focused Updateen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jcmg.2017.07.001
dc.identifier.pmid28882290


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