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dc.contributor.authorScanlon, K.M.
dc.contributor.authorSnyder, Y.G.
dc.contributor.authorSkerry, C.
dc.date.accessioned2019-10-08T19:43:55Z
dc.date.available2019-10-08T19:43:55Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85031903383&doi=10.1128%2fIAI.00355-17&partnerID=40&md5=21e059f8437b183ce9ed8f54f9c2f950
dc.identifier.urihttp://hdl.handle.net/10713/11151
dc.description.abstractIn infants, Bordetella pertussis can cause severe disease, manifested as pronounced leukocytosis, pulmonary hypertension, and even death. The exact cause of death remains unknown, and no effective therapies for treating fulminant pertussis exist. In this study, a neonatal mouse model of critical pertussis is characterized, and a central role for pertussis toxin (PT) is described. PT promoted colonization, leukocytosis, T cell phenotypic changes, systemic pathology, and death in neonatal but not adult mice. Surprisingly, PT inhibited lung inflammatory pathology in neonates, a result which contrasts dramatically with observed PT-promoted pathology in adult mice. Infection with a PT-deficient strain induced severe pulmonary inflammation but not mortality in neonatal mice, suggesting that death in these mice was not associated with impaired lung function. Dissemination of infection beyond the lungs was also detected in neonatal mice, which may contribute to the observed systemic effects of PT. We propose that it is the systemic activity of pertussis toxin and not pulmonary pathology that promotes mortality in critical pertussis. In addition, we observed transmission of infection between neonatal mice, the first report of B. pertussis transmission in mice. This model will be a valuable tool to investigate causes of pertussis pathogenesis and identify potential therapies for critical pertussis.en_US
dc.description.sponsorshipThis work was supported by the National Institute of Allergy and Infectious Diseases, National Institutes of Health (grant numbers AI117095 and AI101055).en_US
dc.description.urihttps://doi.org/10.1128/IAI.00355-17en_US
dc.language.isoen_USen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.relation.ispartofInfection and Immunity
dc.subjectBordetella pertussisen_US
dc.subjectDisseminated infectionen_US
dc.subjectLeukocytosisen_US
dc.subjectNeonatal infectionen_US
dc.subjectPertussis toxinen_US
dc.titleFatal pertussis in the neonatal mouse model is associated with pertussis toxin-mediated pathology beyond the airwaysen_US
dc.typeArticleen_US
dc.identifier.doi10.1128/IAI.00355-17
dc.identifier.pmid28784932


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