Association between endothelial cell density and transplant suitability of corneal tissue with type 1 and type 2 diabetes
Date
2017Journal
JAMA OphthalmologyPublisher
American Medical AssociationType
Article
Metadata
Show full item recordAbstract
IMPORTANCE The rate of types 1 and 2 diabetes in the United States is increasing. The effect of diabetes on corneal donor tissue is unknown. OBJECTIVES To determine the association between endothelial cell density and suitability for transplantation in cornea donors with type 1 or 2 diabetes and determine the effect of diabetes on technician-induced endothelial damage during cornea donor tissue processing. DESIGN, SETTING, AND PARTICIPANTS Donor informationwas obtained from the SightLife Eye Bank for donors from June 1, 2012, to June 30, 2015. The presence of diabetes was determined based on donor medical history. Severe diabetes was classified based on the presence of comorbidities of diabetes. The donor data set contained information on 34 497 donated eyes during the 3-year period, including donor demographics, time from death to refrigeration and preservation of the cornea, endothelial cell count, lens status, medical and surgical history, and suitability for transplantation. MAIN OUTCOMES AND MEASURES Endothelial cell density, suitability for transplantation based on tissue analysis, and technician-induced endothelial damage. RESULTS Among 14 532 donors (mean [SD] age, 58.6 [13.4] years; 8516 men and 6016 women), the mean (SD) endothelial cell count was 2732 (437) cells/mm2. Type 1 or 2 diabetes was listed in the medical history for 8552 of 27 948 donor eyes (30.6%); 5242 eyes (18.8%) were from patients with severe diabetes. After adjusting for age, race/ethnicity, sex, lens status, time from death to refrigeration, and time from death to preservation, the presence of diabetes (adjusted odds ratio, 0.79; 95%CI, 0.51-1.22; P = .28) and severe diabetes (adjusted odds ratio, 95%CI, 0.86; 95%CI, 0.54-1.39; P = .54) were not associated with poor transplant suitability based on results of tissue examination. Donors with diabetes (mean [SD] cell count difference, 9.0 [6.7] cells/mm2; 95%CI,-4.1 to 22.2; P = .18) and severe diabetes (mean [SD] cell count difference, 7.7 [8.1] cells/mm2; 95%CI,-8.1 to 23.6; P = .34) did not exhibit lower cell counts. Technician-induced endothelial damage occurred in 59 corneas (0.2%) but was not associated with the presence of diabetes (adjusted odds ratio, 1.23; 95%CI, 0.66-2.32; P = .52). CONCLUSIONS AND RELEVANCE These data suggest that cornea donors have a high frequency of diabetes. However, this analysis was not able to show that the presence of diabetes was associated with technician-induced endothelial damage, reduced transplant suitability, or reductions in endothelial cell counts. Eye banks may need to collect medical history in a more robust manner. Additional studiesmay be valuable to determine the effect on long-term transplant outcomes of diabetes in cornea donors.Keyword
eye donorsEndothelial Cells
Cornea
Transplants
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Eye Banks
Identifier to cite or link to this item
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014579950&doi=10.1001%2fjamaophthalmol.2016.5095&partnerID=40&md5=010084f6a524ec1c44406fa8f6290f74; http://hdl.handle.net/10713/11137ae974a485f413a2113503eed53cd6c53
10.1001/jamaophthalmol.2016.5095
Scopus Count
Collections
Related articles
- The Effect of Chronic Pulmonary Disease and Mechanical Ventilation on Corneal Donor Endothelial Cell Density and Transplant Suitability.
- Authors: Margo JA, Whiting MF, Brown CH, Hoover CK, Munir WM
- Issue date: 2017 Nov
- Effect of Body Refrigeration Time on Cornea Donor Tissue.
- Authors: Munir WM, Brown CH, Munir SZ, Hoover CK
- Issue date: 2021 Jan 18
- Donor Diabetes Mellitus Severity and Corneal Transplant Suitability in a US Eye Bank Donor Population.
- Authors: Rand GM, Polla DJ, Patel SH, Gore PK, Forest-Smith L, Livesay TM, Chuck RS
- Issue date: 2019 Oct
- The New Zealand National Eye Bank study: trends in the acquisition and storage of corneal tissue over the decade 2000 to 2009.
- Authors: Cunningham WJ, Moffatt SL, Brookes NH, Twohill HC, Pendergrast DG, Stewart JM, McGhee CN
- Issue date: 2012 May
- Assessing the Impact of Diabetes Mellitus on Donor Corneal Endothelial Cell Density.
- Authors: Liaboe CA, Aldrich BT, Carter PC, Skeie JM, Burckart KA, Schmidt GA, Reed CR, Zimmerman MB, Greiner MA
- Issue date: 2017 May