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dc.contributor.authorBlumenthal, J.B.
dc.contributor.authorGitterman, A.
dc.contributor.authorRyan, A.S.
dc.date.accessioned2019-10-08T19:43:52Z
dc.date.available2019-10-08T19:43:52Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85026525703&doi=10.1155%2f2017%2f1492581&partnerID=40&md5=e8eb68f4a341adfa2aee04e0b7143058
dc.identifier.urihttp://hdl.handle.net/10713/11112
dc.description.abstractAerobic exercise training and weight loss (AEX+WL) improves insulin sensitivity in overweight adults; however, the underlying pathways are incompletely understood. Fetuin-A, a hepatokine that inhibits insulin signaling, may be involved in the salutary effects of AEX+WL. Therefore, we examined the effects of 6-month AEX+WL on plasma fetuin-A levels (36–48 hours after the last bout of exercise), aerobic capacity (VO2max), body composition, glucose tolerance, and insulin sensitivity (M) in 16 sedentary, overweight-obese older men (age = 60 ± 2 years, BMI = 31 ± 1 kg/m2) with no history of cardiovascular disease or diabetes. At baseline, fetuin-A levels correlated directly with adiposity and had a borderline inverse correlation with M. After AEX+WL, body weight decreased by ~10 kg, while both VO2max and M increased by 16% ( for all). Contrary to our hypothesis, plasma fetuin-A levels increased after AEX+WL (1.16 ± 0.10 g/L versus 1.70 ± 0.19 g/L, ). This increase was unrelated to changes in body composition or glucose metabolism, but directly correlated with changes in VO2max (, ). Thus, in overweight-to-obese older men, AEX+WL appears to increase plasma fetuin-A levels. Although not associated with improvements in insulin sensitivity, this increase in fetuin-A was related to improvements in aerobic capacity and could be representative of the cardioprotective effects of AEX+WL in older men. Copyright 2017 Jacob B. Blumenthal et al.en_US
dc.description.sponsorshipThis research was supported by a VA Advanced Research Career Development Award, a VA Merit Review Award (Alice S. Ryan), NIH K01-AG-021457, a Paul B. Beeson Patient-Oriented Research Career Development Award in Aging (NIH K23-AG040775), VA Career Development Awards, the University of Maryland Claude D. Pepper Center (NIH P30-AG028747), the Mid-Atlantic Nutrition Obesity Research Center (P30-DK072488), and the Baltimore Veterans Affairs Medical Center Geriatric Research, Education and Clinical Center (GRECC).en_US
dc.description.urihttps://doi.org/10.1155/2017/1492581en_US
dc.language.isoen_USen_US
dc.publisherHindawi Limiteden_US
dc.relation.ispartofJournal of Diabetes Research
dc.subject.meshExercise Therapyen_US
dc.subject.meshHealthy Dieten_US
dc.subject.meshInsulin Resistanceen_US
dc.subject.meshOverweighten_US
dc.subject.meshWeight Lossen_US
dc.subject.meshalpha-2-HS-Glycoprotein--metabolismen_US
dc.titleEffects of Exercise Training and Weight Loss on Plasma Fetuin-A Levels and Insulin Sensitivity in Overweight Older Menen_US
dc.typeArticleen_US
dc.identifier.doi10.1155/2017/1492581
dc.identifier.pmid28770230


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