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dc.contributor.authorZhang, P.
dc.contributor.authorBookstaver, M.L.
dc.contributor.authorJewell, C.M.
dc.date.accessioned2019-10-08T19:43:51Z
dc.date.available2019-10-08T19:43:51Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85013653833&doi=10.3390%2fpolym9020040&partnerID=40&md5=3abc77838bc4c4b559acdf2b5559a786
dc.identifier.urihttp://hdl.handle.net/10713/11105
dc.description.abstractEngineering cell surfaces with natural or synthetic materials is a unique and powerful strategy for biomedical applications. Cells exhibit more sophisticated migration, control, and functional capabilities compared to nanoparticles, scaffolds, viruses, and other engineered materials or agents commonly used in the biomedical field. Over the past decade, modification of cell surfaces with natural or synthetic materials has been studied to exploit this complexity for both fundamental and translational goals. In this review we present the existing biomedical technologies for engineering cell surfaces with one important class of materials, polyelectrolytes. We begin by introducing the challenges facing the cell surface engineering field. We then discuss the features of polyelectrolytes and how these properties can be harnessed to solve challenges in cell therapy, tissue engineering, cell-based drug delivery, sensing and tracking, and immune modulation. Throughout the review, we highlight opportunities to drive the field forward by bridging new knowledge of polyelectrolytes with existing translational challenges. Copyright 2017 by the authors.en_US
dc.description.sponsorshipThis work was supported in part by NSF CAREER Award # 1351688. Christopher M. Jewell is a Damon Runyon-Rachleff Innovator supported by the Damon Runyon Foundation (# DRR3415), and a Young Investigator of the Alliance for Cancer Gene Therapy (# 15051543) and the Melanoma Research Alliance (# 348963).en_US
dc.description.urihttps://doi.org/10.3390/polym9020040en_US
dc.language.isoen_USen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofPolymers
dc.subjectCell modificationen_US
dc.subjectDrug deliveryen_US
dc.subjectMultilayeren_US
dc.subjectPolyelectrolyteen_US
dc.subjectRegenerative medicineen_US
dc.subjectSensing and signalingen_US
dc.subjectSurface proteinen_US
dc.subjectTissue engineeringen_US
dc.subjectVaccine and immunotherapyen_US
dc.titleEngineering cell surfaces with polyelectrolyte materials for translational applicationsen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/polym9020040


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