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dc.contributor.authorWikenheiser, A.M.
dc.contributor.authorMarrero-Garcia, Y.
dc.contributor.authorSchoenbaum, G.
dc.date.accessioned2019-10-08T19:43:51Z
dc.date.available2019-10-08T19:43:51Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85027507242&doi=10.1016%2fj.neuron.2017.08.003&partnerID=40&md5=c8582740162f86e8e7f426317d17f946
dc.identifier.urihttp://hdl.handle.net/10713/11100
dc.description.abstractThe hippocampus and orbitofrontal cortex (OFC) both make important contributions to decision making and other cognitive processes. However, despite anatomical links between the two, few studies have tested the importance of hippocampal–OFC interactions. Here, we recorded OFC neurons in rats performing a decision making task while suppressing activity in a key hippocampal output region, the ventral subiculum. OFC neurons encoded information about expected outcomes and rats’ responses. With hippocampal output suppressed, rats were slower to adapt to changes in reward contingency, and OFC encoding of response information was strongly attenuated. In addition, ventral subiculum inactivation prevented OFC neurons from integrating information about features of outcomes to form holistic representations of the outcomes available in specific trial blocks. These data suggest that the hippocampus contributes to OFC encoding of both concrete, low-level features of expected outcomes, and abstract, inferred properties of the structure of the world, such as task state.en_US
dc.description.urihttps://doi.org/10.1016/j.neuron.2017.08.003en_US
dc.language.isoen_USen_US
dc.publisherCell Pressen_US
dc.relation.ispartofNeuron
dc.subjectdecision makingen_US
dc.subjectdecodingen_US
dc.subjectelectrophysiologyen_US
dc.subjecthippocampusen_US
dc.subjectorbitofrontalen_US
dc.titleSuppression of Ventral Hippocampal Output Impairs Integrated Orbitofrontal Encoding of Task Structureen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.neuron.2017.08.003
dc.identifier.pmid28823726


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