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dc.contributor.authorOrtmeyer, H.K.
dc.contributor.authorGoldberg, A.P.
dc.contributor.authorRyan, A.S.
dc.date.accessioned2019-10-08T19:43:50Z
dc.date.available2019-10-08T19:43:50Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85019757668&doi=10.1002%2foby.21877&partnerID=40&md5=30208d0ff3d28752caca1eb0a1ead731
dc.identifier.urihttp://hdl.handle.net/10713/11084
dc.description.abstractObjective: The effects of 6-month weight loss (WL) versus aerobic exercise training (AEX)+WL on fat and skeletal muscle markers of fatty acid metabolism were determined in normal (NGT) and impaired (IGT) glucose tolerant African-American and Caucasian postmenopausal women with overweight/obesity. Methods: Fat (gluteal and abdominal) lipoprotein lipase (LPL), skeletal muscle LPL, acyl-CoA synthase (ACS), ß‐hydroxacyl‐CoA dehydrogenase, carnitine palmitoyltransferase (CPT-1), and citrate synthase (CS) activities were measured at baseline (n = 104) and before and after WL (n = 34) and AEX+WL (n = 37). Results: After controlling for age and race, muscle LPL and CPT-1 were lower in IGT, and the ratios of fat/muscle LPL activity were higher in IGT compared to NGT. Muscle LPL was related to insulin sensitivity (M value) and inversely related to G120, fasting insulin, and homeostatic model assessment of insulin resistance. AEX+WL decreased abdominal fat LPL and increased muscle LPL, ACS, and CS. The ratios of fat/muscle LPL decreased after AEX+WL. The change in VO2max was related to the changes in LPL, ACS, and CS and inversely related to the changes in fat/muscle LPL activity ratios. Conclusions: Six-month AEX+WL, and not WL alone, is capable of enhancing skeletal muscle fatty acid metabolism in postmenopausal African-American and Caucasian women with NGT, IGT, and overweight/obesity.en_US
dc.description.sponsorshipen_US
dc.description.urihttps://doi.org/10.1002/oby.21877en_US
dc.language.isoen_USen_US
dc.publisherBlackwell Publishing Inc.en_US
dc.relation.ispartofObesity
dc.subject.meshBiomarkersen_US
dc.subject.meshExerciseen_US
dc.subject.meshLipid Metabolismen_US
dc.subject.meshMuscle, Skeletal--metabolismen_US
dc.subject.meshObesityen_US
dc.subject.meshOverweighten_US
dc.subject.meshWeight Lossen_US
dc.subject.meshPostmenopauseen_US
dc.subject.meshFemaleen_US
dc.titleExercise with weight loss improves adipose tissue and skeletal muscle markers of fatty acid metabolism in postmenopausal womenen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/oby.21877
dc.identifier.pmid28547918


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