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    Exercise with weight loss improves adipose tissue and skeletal muscle markers of fatty acid metabolism in postmenopausal women

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    Author
    Ortmeyer, H.K.
    Goldberg, A.P.
    Ryan, A.S.
    Date
    2017
    Journal
    Obesity
    Publisher
    Blackwell Publishing Inc.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1002/oby.21877
    Abstract
    Objective: The effects of 6-month weight loss (WL) versus aerobic exercise training (AEX)+WL on fat and skeletal muscle markers of fatty acid metabolism were determined in normal (NGT) and impaired (IGT) glucose tolerant African-American and Caucasian postmenopausal women with overweight/obesity. Methods: Fat (gluteal and abdominal) lipoprotein lipase (LPL), skeletal muscle LPL, acyl-CoA synthase (ACS), ß‐hydroxacyl‐CoA dehydrogenase, carnitine palmitoyltransferase (CPT-1), and citrate synthase (CS) activities were measured at baseline (n = 104) and before and after WL (n = 34) and AEX+WL (n = 37). Results: After controlling for age and race, muscle LPL and CPT-1 were lower in IGT, and the ratios of fat/muscle LPL activity were higher in IGT compared to NGT. Muscle LPL was related to insulin sensitivity (M value) and inversely related to G120, fasting insulin, and homeostatic model assessment of insulin resistance. AEX+WL decreased abdominal fat LPL and increased muscle LPL, ACS, and CS. The ratios of fat/muscle LPL decreased after AEX+WL. The change in VO2max was related to the changes in LPL, ACS, and CS and inversely related to the changes in fat/muscle LPL activity ratios. Conclusions: Six-month AEX+WL, and not WL alone, is capable of enhancing skeletal muscle fatty acid metabolism in postmenopausal African-American and Caucasian women with NGT, IGT, and overweight/obesity.
    Keyword
    Biomarkers
    Exercise
    Lipid Metabolism
    Muscle, Skeletal--metabolism
    Obesity
    Overweight
    Weight Loss
    Postmenopause
    Female
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019757668&doi=10.1002%2foby.21877&partnerID=40&md5=30208d0ff3d28752caca1eb0a1ead731; http://hdl.handle.net/10713/11084
    ae974a485f413a2113503eed53cd6c53
    10.1002/oby.21877
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