Show simple item record

dc.contributor.authorLaKind, J.S.
dc.contributor.authorAnthony, L.G.
dc.contributor.authorGoodman, M.
dc.date.accessioned2019-10-08T19:43:49Z
dc.date.available2019-10-08T19:43:49Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85030153720&doi=10.1080%2f10937404.2017.1370847&partnerID=40&md5=cf12b3b2c8ccc0afa050120a210487b1
dc.identifier.urihttp://hdl.handle.net/10713/11071
dc.description.abstractEnvironmental epidemiology data are becoming increasingly important in public health decision making, which commonly incorporates a systematic review of multiple studies. This review addresses two fundamental questions: What is the quality of available reviews on associations between exposure to synthetic organic chemicals and neurodevelopmental outcomes? What is the value (e.g., quality and consistency) of the underlying literature? Published reviews on associations between synthetic organic environmental chemical exposures and neurodevelopmental outcomes in children were systematically evaluated. Seventy-four relevant reviews were identified, and these were evaluated with respect to four methodological characteristics: (1) systematic inclusion/exclusion criteria and reproducible methods for search and retrieval of studies; (2) structured evaluation of underlying data quality; (3) systematic assessment of consistency across specific exposure-outcome associations; and (4) evaluation of reporting/publication bias. None of the 74 reviews fully met the criteria for all four methodological characteristics. Only four reviews met two criteria, and six reviews fulfilled only one criterion. Perhaps more importantly, the higher quality reviews were not able to meet all of the criteria owing to the shortcomings of underlying studies, which lacked comparability in terms of specific research question of interest, overall design, exposure assessment, outcome ascertainment, and analytic methods. Thus, even the most thoughtful and rigorous review may be of limited value if the underlying literature includes investigations that address different hypotheses and are beset by methodological inconsistencies and limitations. Issues identified in this review of reviews illustrate considerable challenges that are facing assessments of epidemiological evidence. Copyright 2017 The Author(s).en_US
dc.description.sponsorshipen_US
dc.description.urihttps://doi.org/10.1080/10937404.2017.1370847en_US
dc.language.isoen_USen_US
dc.publisherTaylor and Francis Inc.en_US
dc.relation.ispartofJournal of Toxicology and Environmental Health - Part B: Critical Reviews
dc.subjectEnvironmental chemicalen_US
dc.subjectepidemiologyen_US
dc.subjectneurodevelopmenten_US
dc.subjectPECOen_US
dc.subjectsystematic reviewen_US
dc.titleReview of reviews on exposures to synthetic organic chemicals and children's neurodevelopment: Methodological and interpretation challengesen_US
dc.typeArticleen_US
dc.identifier.doi10.1080/10937404.2017.1370847
dc.identifier.pmid28952888


This item appears in the following Collection(s)

Show simple item record