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dc.contributor.authorJohn, C.C.
dc.contributor.authorBlack, M.M.
dc.contributor.authorNelson, C.A.
dc.date.accessioned2019-10-08T19:43:48Z
dc.date.available2019-10-08T19:43:48Z
dc.date.issued2017
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85017619984&doi=10.1542%2fpeds.2016-2828H&partnerID=40&md5=535024764659a6c961633ccd43767f9b
dc.identifier.urihttp://hdl.handle.net/10713/11067
dc.description.abstractThe early to middle childhood years are a critical period for child neurodevelopment. Nutritional deficiencies, infection, and inflammation are major contributors to impaired child neurodevelopment in these years, particularly in low-resource settings. This review identifies global research priorities relating to nutrition, infection, and inflammation in early to middle childhood neurodevelopment. The research priority areas identified include: (1) assessment of how nutrition, infection, or inflammation in the preconception, prenatal, and infancy periods (or interventions in these periods) affect function in early to middle childhood; (2) assessment of whether effects of nutritional interventions vary by poverty or inflammation; (3) determination of the feasibility of preschool-and school-based integrated nutritional interventions; (4) improved assessment of the epidemiology of infectionand inflammation-related neurodevelopmental impairment (NDi); (5) identification of mechanisms through which infection causes NDi; (6) identification of noninfectious causes of inflammation-related NDi and interventions for causes already identified (eg, environmental factors); and (7) studies on the effects of interactions between nutritional, infectious, and inflammatory factors on neurodevelopment in early to middle childhood. Areas of emerging importance that require additional study include the effects of maternal Zika virus infection, childhood environmental enteropathy, and alterations in the child's microbiome on neurodevelopment in early to middle childhood. Research in these key areas will be critical to the development of interventions to optimize the neurodevelopmental potential of children worldwide in the early to middle childhood years. Copyright 2017 by the American Academy of Pediatrics.en_US
dc.description.urihttps://www.ncbi.nlm.nih.gov/pubmed/28562249en_US
dc.language.isoen_USen_US
dc.publisherAmerican Academy of Pediatricsen_US
dc.relation.ispartofPediatrics
dc.subject.meshBrain--growth & developmenten_US
dc.subject.meshChild Development--physiologyen_US
dc.subject.meshChild Nutritional Physiological Phenomenaen_US
dc.subject.meshInflammation--physiopathologyen_US
dc.subject.meshNutritional Statusen_US
dc.subject.meshPovertyen_US
dc.titleNeurodevelopment: The impact of nutrition and inflammation during early to middle childhood in low-resource settingsen_US
dc.typeArticleen_US
dc.identifier.doi10.1542/peds.2016-2828H
dc.identifier.pmid28562249


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