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    Stem cell transplantation for peripheral nerve regeneration: Current options and opportunities

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    Author
    Jiang, L.
    Jones, S.
    Jia, X.
    Date
    2017
    Journal
    International Journal of Molecular Sciences
    Publisher
    MDPI AG
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3390/ijms18010094
    Abstract
    Peripheral nerve regeneration is a complicated process highlighted by Wallerian degeneration, axonal sprouting, and remyelination. Schwann cells play an integral role in multiple facets of nerve regeneration but obtaining Schwann cells for cell-based therapy is limited by the invasive nature of harvesting and donor site morbidity. Stem cell transplantation for peripheral nerve regeneration offers an alternative cell-based therapy with several regenerative benefits. Stem cells have the potential to differentiate into Schwann-like cells that recruit macrophages for removal of cellular debris. They also can secrete neurotrophic factors to promote axonal growth, and remyelination. Currently, various types of stem cell sources are being investigated for their application to peripheral nerve regeneration. This review highlights studies involving the stem cell types, the mechanisms of their action, methods of delivery to the injury site, and relevant pre-clinical or clinical data. The purpose of this article is to review the current point of view on the application of stem cell based strategy for peripheral nerve regeneration. Copyright 2017 by the authors; licensee MDPI, Basel, Switzerland.
    Keyword
    Peripheral nerve
    Regeneration
    Stem cells
    Transplantation
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009291525&doi=10.3390%2fijms18010094&partnerID=40&md5=ba105a0106fa3f12563edbcece25f3a2; http://hdl.handle.net/10713/11066
    ae974a485f413a2113503eed53cd6c53
    10.3390/ijms18010094
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    UMB Open Access Articles 2017

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