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    Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross

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    Author
    Kaslow, S.R.
    Kim, A.
    Sá, J.M.
    Date
    2019
    Journal
    Nature communications
    Publisher
    Nature Publishing Group
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1038/s41467-019-12256-9
    Abstract
    Mainstay treatment for Plasmodium vivax malaria has long relied on chloroquine (CQ) against blood-stage parasites plus primaquine against dormant liver-stage forms (hypnozoites), however drug resistance confronts this regimen and threatens malaria control programs. Understanding the basis of P. vivax chloroquine resistance (CQR) will inform drug discovery and malaria control. Here we investigate the genetics of P. vivax CQR by a cross of parasites differing in drug response. Gametocytogenesis, mosquito infection, and progeny production are performed with mixed parasite populations in nonhuman primates, as methods for P. vivax cloning and in vitro cultivation remain unavailable. Linkage mapping of progeny surviving >15 mg/kg CQ identifies a 76 kb region in chromosome 1 including pvcrt, an ortholog of the Plasmodium falciparum CQR transporter gene. Transcriptional analysis supports upregulated pvcrt expression as a mechanism of CQR.
    Keyword
    parasite genetics
    Drug Resistance, Microbial
    Antiparasitic Agents
    Malaria
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072540054&doi=10.1038%2fs41467-019-12256-9&partnerID=40&md5=5f8689e94669350e162d4e0def357f30; http://hdl.handle.net/10713/11038
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41467-019-12256-9
    Scopus Count
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    UMB Open Access Articles 2019

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