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    Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis

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    Author
    Kant, S.
    Craige, S.M.
    Reif, M.M.
    Date
    2019
    Journal
    Nature communications
    Publisher
    Nature Publishing Group
    Type
    Article
    
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    See at
    https://doi.org/10.1038/s41467-019-11982-4
    Abstract
    Diseases related to impaired blood flow such as peripheral artery disease (PAD) impact nearly 10 million people in the United States alone, yet patients with clinical manifestations of PAD (e.g., claudication and limb ischemia) have limited treatment options. In ischemic tissues, stress kinases such as c-Jun N-terminal kinases (JNKs), are activated. Here, we show that inhibition of the JNK3 (Mapk10) in the neural compartment strikingly potentiates blood flow recovery from mouse hindlimb ischemia. JNK3 deficiency leads to upregulation of growth factors such as Vegfa, Pdgfb, Pgf, Hbegf and Tgfb3 in ischemic muscle by activation of the transcription factors Egr1/Creb1. JNK3 acts through Forkhead box O3 (Foxo3a) to suppress the activity of Egr1/Creb1 transcription regulators in vitro. In JNK3-deficient cells, Foxo3a is suppressed which leads to Egr1/Creb1 activation and upregulation of downstream growth factors. Collectively, these data suggest that the JNK3-Foxo3a-Egr1/Creb1 axis coordinates the vascular remodeling response in peripheral ischemia.
    Keyword
    Peripheral Artery Disease--physiopathology
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072293680&doi=10.1038%2fs41467-019-11982-4&partnerID=40&md5=464317d0f168b8fc6dce27582b27c413; http://hdl.handle.net/10713/11037
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41467-019-11982-4
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