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dc.contributor.authorBruce, H.A.
dc.contributor.authorKochunov, P.
dc.contributor.authorMitchell, B.
dc.contributor.authorStrauss, K.A.
dc.contributor.authorAment, S.A.
dc.contributor.authorRowland, L.M.
dc.contributor.authorDu, X.
dc.contributor.authorFisseha, F.
dc.contributor.authorKavita, T.
dc.contributor.authorChiappelli, J.
dc.contributor.authorWisner, K.
dc.contributor.authorSampath, H.
dc.contributor.authorChen, S.
dc.contributor.authorKvarta, M.D.
dc.contributor.authorPostolache, T.T.
dc.contributor.authorShuldiner, A.
dc.contributor.authorElliot, Hong, L.
dc.contributor.authorSeneviratne, C.en_US
dc.date.accessioned2019-09-26T19:38:38Z
dc.date.available2019-09-26T19:38:38Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85072300292&doi=10.1038%2fs41398-019-0561-z&partnerID=40&md5=493121f0ee73482d341692a0b105eeca
dc.identifier.urihttp://hdl.handle.net/10713/11024
dc.description.abstractResearch has yet to provide a comprehensive understanding of the genetic basis of bipolar disorder (BP). In genetic studies, defining the phenotype by diagnosis may miss risk-allele carriers without BP. The authors aimed to test whether quantitatively detected subclinical symptoms of bipolarity identifies a heritable trait that infers risk for BP. The Quantitative Bipolarity Scale (QBS) was administered to 310 Old Order Amish or Mennonite individuals from multigenerational pedigrees; 110 individuals had psychiatric diagnoses (20 BP, 61 major depressive disorders (MDD), 3 psychotic disorders, 26 other psychiatric disorders). Familial aggregation of QBS was calculated using the variance components method to derive heritability and shared household effects. The QBS score was significantly higher in BP subjects (31.5 ± 3.6) compared to MDD (16.7 ± 2.0), other psychiatric diagnoses (7.0 ± 1.9), and no psychiatric diagnosis (6.0 ± 0.65) (all p < 0.001). QBS in the whole sample was significantly heritable (h2 = 0.46 ± 0.15, p < 0.001) while the variance attributed to the shared household effect was not significant (p = 0.073). When subjects with psychiatric illness were removed, the QBS heritability was similar (h2 = 0.59 ± 0.18, p < 0.001). These findings suggest that quantitative bipolarity as measured by QBS can separate BP from other psychiatric illnesses yet is significantly heritable with and without BP included in the pedigrees suggesting that the quantitative bipolarity describes a continuous heritable trait that is not driven by a discrete psychiatric diagnosis. Bipolarity trait assessment may be used to supplement the diagnosis of BP in future genetic studies and could be especially useful for capturing subclinical genetic contributions to a BP phenotype.en_US
dc.description.urihttps://doi.org/10.1038/s41398-019-0561-zen_US
dc.language.isoen-USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofTranslational psychiatry
dc.subjectQuantitative Bipolarity Scaleen_US
dc.subject.meshBipolar Disorder--diagnosisen_US
dc.subject.meshBipolar Disorder--geneticsen_US
dc.titleClinical and genetic validity of quantitative bipolarityen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41398-019-0561-z
dc.identifier.pmid31527585


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