Show simple item record

dc.contributor.authorMacario, Alberto J. L.
dc.contributor.authorCaruso Bavisotto, Celeste
dc.contributor.authorConway de Macario, Everly
dc.date.accessioned2019-09-23T15:13:56Z
dc.date.available2019-09-23T15:13:56Z
dc.date.issued2019
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85072145205&doi=10.3390%2fijms20184496&partnerID=40&md5=4686ce8389c4e29c544a144b539b5f47
dc.identifier.urihttp://hdl.handle.net/10713/11009
dc.description.abstractThe thyroid is a major component of the endocrine system and its pathology can cause serious diseases, e.g., papillary carcinoma (PC). However, the carcinogenic mechanisms are poorly understood and clinical useful biomarkers are scarce. Therefore, we determined if there are quantitative patterns of molecular chaperones in the tumor tissue and circulating exosomes that may be useful in diagnosis and provide clues on their participation in carcinogenesis. Hsp27, Hsp60, Hsp70, and Hsp90 were quantified by immunohistochemistry in PC, benign goiter (BG), and normal peritumoral tissue (PT). The same chaperones were assessed in plasma exosomes from PC and BG patients before and after ablative surgery, using Western blotting. Hsp27, Hsp60, and Hsp90 were increased in PC in comparison with PT and BG but no differences were found for Hsp70. Similarly, exosomal levels of Hsp27, Hsp60, and Hsp90 were higher in PC than in BG, and those in PC were higher before ablative surgery than after it. Hsp27, Hsp60, and Hsp90 show distinctive quantitative patterns in thyroid tissue and circulating exosomes in PC as compared with BG, suggesting some implication in the carcinogenesis of these chaperones and indicating their potential as biomarkers for clinical applications.en_US
dc.description.sponsorshipPart of this work was funded by the Italian National Operational Programme (PON) «Imprese e Competitività» 2014-2020 FESR (Project code: F/090012/01-02/X36).en_US
dc.description.urihttps://doi.org/10.3390/ijms20184496en_US
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.relation.ispartofInternational journal of molecular sciences
dc.subjectdiagnosisen_US
dc.subjectexosomesen_US
dc.subjectgoiteren_US
dc.subjectheat shock proteins (Hsp)en_US
dc.subjectmolecular chaperonesen_US
dc.subjectpapillary carcinomaen_US
dc.subjectthyroid glanden_US
dc.titleImmunomorphological Pattern of Molecular Chaperones in Normal and Pathological Thyroid Tissues and Circulating Exosomes: Potential Use in Clinicsen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/ijms20184496
dc.identifier.pmid31514388


This item appears in the following Collection(s)

Show simple item record