Conserved signatures indicate HIV-1 transmission is under strong selection and thus is not a "stochastic" process
PublisherBioMed Central Ltd.
MetadataShow full item record
AbstractRecently, Oberle et al. published a paper in Retrovirology evaluating the question of whether selection plays a role in HIV transmission. The Oberle study found no obvious genotypic or phenotypic differences between donors and recipients of epidemiologically linked pairs from the Swiss cohort. Thus, Oberle et al. characterized HIV-1 B transmission as largely "stochastic", an imprecise and potentially misleading term. Here, we re-analyzed their data and placed them in the context of transmission data for over 20 other human and animal trials. The present study finds that the transmitted/founder (T/F) viruses from the Swiss cohort show the same non-random genetic signatures conserved in 118 HIV-1, 40 SHIV, and 12 SIV T/F viruses previously published by two independent groups. We provide alternative interpretations of the Swiss cohort data and conclude that the sequences of their donor viruses lacked variability at the specific sites where other studies were able to demonstrate genotypic selection. Oberle et al. observed no phenotypic selection in vitro, so the problem of determining the in vivo phenotypic mechanisms that cause genotypic selection in HIV remains open. Copyright 2017 The Author(s).
KeywordPhenotypic versus genotypic selection
Selection during HIV transmission
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85013742100&doi=10.1186%2fs12977-016-0326-1&partnerID=40&md5=d8223a2bc33836f52435cee143482249; http://hdl.handle.net/10713/11000
- Conserved molecular signatures in gp120 are associated with the genetic bottleneck during simian immunodeficiency virus (SIV), SIV-human immunodeficiency virus (SHIV), and HIV type 1 (HIV-1) transmission.
- Authors: Gonzalez MW, DeVico AL, Lewis GK, Spouge JL
- Issue date: 2015 Apr
- Tracing HIV-1 transmission: envelope traits of HIV-1 transmitter and recipient pairs.
- Authors: Oberle CS, Joos B, Rusert P, Campbell NK, Beauparlant D, Kuster H, Weber J, Schenkel CD, Scherrer AU, Magnus C, Kouyos R, Rieder P, Niederöst B, Braun DL, Pavlovic J, Böni J, Yerly S, Klimkait T, Aubert V, Trkola A, Metzner KJ, Günthard HF, Swiss HIV Cohort Study (SHCS).
- Issue date: 2016 Sep 5
- Reply to correspondence 'Conserved signatures indicate HIV-1 transmission is under strong selection and thus is not a "stochastic" process' by Gonzalez et al., Retrovirology 2017.
- Authors: Oberle CS, Magnus C, Joos B, Rusert P, Beauparlant D, Kouyos R, Trkola A, Metzner KJ, Günthard HF
- Issue date: 2017 Feb 24
- Breast milk and in utero transmission of HIV-1 select for envelope variants with unique molecular signatures.
- Authors: Nakamura KJ, Heath L, Sobrera ER, Wilkinson TA, Semrau K, Kankasa C, Tobin NH, Webb NE, Lee B, Thea DM, Kuhn L, Mullins JI, Aldrovandi GM
- Issue date: 2017 Jan 26
- HIV transmission.
- Authors: Shaw GM, Hunter E
- Issue date: 2012 Nov 1